AIMC Topic: DNA Breaks, Double-Stranded
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Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells.
STAR protocols
Jul 31, 2024
The nuclear envelope can form complex structures in physiological and pathological contexts. Current approaches to quantify nuclear envelope structures can be time-consuming or inaccurate. Here, we present a protocol to measure nuclear envelope tubul...
A deep learning model (FociRad) for automated detection of γ-H2AX foci and radiation dose estimation.
Scientific reports
Apr 1, 2022
DNA double-strand breaks (DSBs) are the most lethal form of damage to cells from irradiation. γ-H2AX (phosphorylated form of H2AX histone variant) has become one of the most reliable and sensitive biomarkers of DNA DSBs. However, the γ-H2AX foci assa...
Unlocking HDR-mediated nucleotide editing by identifying high-efficiency target sites using machine learning.
Scientific reports
Feb 26, 2019
Editing individual nucleotides is a crucial component for validating genomic disease association. It is currently hampered by CRISPR-Cas-mediated "base editing" being limited to certain nucleotide changes, and only achievable within a small window ar...
The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.
Oxidative medicine and cellular longevity
Dec 14, 2015
Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe. This species is known to have antibacterial, anti-inflammatory, and antioxidant activity and has demonstrated a reduction of intracellular reac...
DNA Damage
Chromatography, High Pressure Liquid
Plant Extracts
Spectrometry, Mass, Electrospray Ionization
Animals
Regeneration
Gene Expression Regulation
Wound Healing
DNA Breaks, Double-Stranded
CHO Cells
Antioxidants
Cell Survival
DNA Repair
Cricetulus
Protective Agents
Cytoprotection
Oxidation-Reduction
Leonurus
Cricetinae
Phenols
Robotic radiation shielding system reduces radiation-induced DNA damage in operators performing electrophysiological procedures.
Scientific reports
May 28, 2025
Fluoroscopically guided electrophysiology (EP) procedures expose operators to low doses of ionizing radiation, which can induce DNA double-strand breaks (DSBs) and raises increasing concerns regarding potential health risks. A novel robotic radiation...
Revisiting CRISPR/Cas-mediated crop improvement: Special focus on nutrition.
Journal of biosciences
Jan 1, 2020
Genome editing (GE) technology has emerged as a multifaceted strategy that instantaneously popularised the mechanism to modify the genetic constitution of an organism. The clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-a...
Genotoxicity in lead treated human lymphocytes evaluated by micronucleus and comet assays.
Indian journal of experimental biology
Aug 1, 2016
Lead (Pb) which plays a significant role in modern industry is related to a broad range of physiological, biochemical, behavioural and genetical dysfunctions. Its exposure leads to an increased frequency of genetic aberrations in humans. Hence, this ...
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