Journal of the American Medical Informatics Association : JAMIA
Mar 1, 2020
OBJECTIVE: We developed medExtractR, a natural language processing system to extract medication information from clinical notes. Using a targeted approach, medExtractR focuses on individual drugs to facilitate creation of medication-specific research...
INTRODUCTION: The research and development of drugs, related to the central nervous system (CNS) diseases is a long and arduous process with high cost, long cycle and low success rate. Identification of key features based on available CNS drugs is of...
Protein-related interaction prediction is critical to understanding life processes, biological functions, and mechanisms of drug action. Experimental methods used to determine proteinrelated interactions have always been costly and inefficient. In re...
Journal of the American Medical Informatics Association : JAMIA
Jan 1, 2020
OBJECTIVE: This article presents our approaches to extraction of medications and associated adverse drug events (ADEs) from clinical documents, which is the second track of the 2018 National NLP Clinical Challenges (n2c2) shared task.
Journal of the American Medical Informatics Association : JAMIA
Dec 1, 2019
OBJECTIVE: Twitter posts are now recognized as an important source of patient-generated data, providing unique insights into population health. A fundamental step toward incorporating Twitter data in pharmacoepidemiologic research is to automatically...
The modes of action (MoAs) of drugs frequently are unknown, because many are small molecules initially identified from phenotypic screens, giving rise to the need to elucidate their MoAs. In addition, the high attrition rate for candidate drugs in pr...
MOTIVATION: Historically, gene expression has been shown to be the most informative data for drug response prediction. Recent evidence suggests that integrating additional omics can improve the prediction accuracy which raises the question of how to ...
BACKGROUND: Determination or prediction of the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of drug candidates and drug-induced toxicity plays crucial roles in drug discovery and development. Metabolism is one of the most com...
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