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Pharmacovigilance

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Leveraging digital media data for pharmacovigilance.

AMIA ... Annual Symposium proceedings. AMIA Symposium
The development of novel drugs in response to changing clinical requirements is a complex and costly method with uncertain outcomes. Postmarket pharmacovigilance is essential as drugs often have under-reported side effects. This study intends to use ...

Semiautomated Approach for Muscle Weakness Detection in Clinical Texts.

Studies in health technology and informatics
The automated detection of adverse events in medical records might be a cost-effective solution for patient safety management or pharmacovigilance. Our group proposed an information extraction algorithm (IEA) for detecting adverse events in neurosurg...

Artificial Intelligence, Real-World Automation and the Safety of Medicines.

Drug safety
Despite huge technological advances in the capabilities to capture, store, link and analyse data electronically, there has been some but limited impact on routine pharmacovigilance. We discuss emerging research in the use of artificial intelligence, ...

Artificial Intelligence in Pharmacovigilance: Scoping Points to Consider.

Clinical therapeutics
Artificial intelligence (AI), a highly interdisciplinary science, is an increasing presence in pharmacovigilance (PV). A better understanding of the scope of artificial intelligence in pharmacovigilance (AIPV) may be advantageous to more sharply defi...

Validating Intelligent Automation Systems in Pharmacovigilance: Insights from Good Manufacturing Practices.

Drug safety
Pharmacovigilance is the science of monitoring the effects of medicinal products to identify and evaluate potential adverse reactions and provide necessary and timely risk mitigation measures. Intelligent automation technologies have a strong potenti...

Artificial Intelligence for Unstructured Healthcare Data: Application to Coding of Patient Reporting of Adverse Drug Reactions.

Clinical pharmacology and therapeutics
Adverse drug reaction (ADR) reporting is a major component of drug safety monitoring; its input will, however, only be optimized if systems can manage to deal with its tremendous flow of information, based primarily on unstructured text fields. The a...

AI-based language models powering drug discovery and development.

Drug discovery today
The discovery and development of new medicines is expensive, time-consuming, and often inefficient, with many failures along the way. Powered by artificial intelligence (AI), language models (LMs) have changed the landscape of natural language proces...

Explainable artificial intelligence for pharmacovigilance: What features are important when predicting adverse outcomes?

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Explainable Artificial Intelligence (XAI) has been identified as a viable method for determining the importance of features when making predictions using Machine Learning (ML) models. In this study, we created models that ta...

DeepADEMiner: a deep learning pharmacovigilance pipeline for extraction and normalization of adverse drug event mentions on Twitter.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Research on pharmacovigilance from social media data has focused on mining adverse drug events (ADEs) using annotated datasets, with publications generally focusing on 1 of 3 tasks: ADE classification, named entity recognition for identify...

A contextual multi-task neural approach to medication and adverse events identification from clinical text.

Journal of biomedical informatics
Effective wide-scale pharmacovigilance calls for accurate named entity recognition (NER) of medication entities such as drugs, dosages, reasons, and adverse drug events (ADE) from clinical text. The scarcity of adverse event annotations and underlyin...