AIMC Topic: Precision Medicine

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Sweat Proteomics in Cystic Fibrosis: Discovering Companion Biomarkers for Precision Medicine and Therapeutic Development.

Cells
In clinical routine, the diagnosis of cystic fibrosis (CF) is still challenging regardless of international consensus on diagnosis guidelines and tests. For decades, the classical Gibson and Cooke test measuring sweat chloride concentration has been ...

Artificial intelligence in anatomical pathology: building a strong foundation for precision medicine.

Human pathology
With the convergence of digital pathology (DP) and artificial intelligence (AI), anatomic pathology practice has been experiencing an exciting paradigm shifting. Pathologists will be provided with an augmented ability to improve diagnostic accuracy, ...

Dimensionality reduction of longitudinal 'omics data using modern tensor factorizations.

PLoS computational biology
Longitudinal 'omics analytical methods are extensively used in the evolving field of precision medicine, by enabling 'big data' recording and high-resolution interpretation of complex datasets, driven by individual variations in response to perturbat...

Industrializing AI-powered drug discovery: lessons learned from the computing platform.

Expert opinion on drug discovery
INTRODUCTION: As a mid-size international pharmaceutical company, we initiated 4 years ago the launch of a dedicated high-throughput computing platform supporting drug discovery. The platform named ' was built up on the initial predicate to capitaliz...

Multiomics, artificial intelligence, and precision medicine in perinatology.

Pediatric research
Technological advances in omics evaluation, bioinformatics, and artificial intelligence have made us rethink ways to improve patient outcomes. Collective quantification and characterization of biological data including genomics, epigenomics, metabolo...

Applications of artificial intelligence multiomics in precision oncology.

Journal of cancer research and clinical oncology
Cancer is the second leading worldwide disease that depends on oncogenic mutations and non-mutated genes for survival. Recent advancements in next-generation sequencing (NGS) have transformed the health care sector with big data and machine learning ...

Artificial intelligence and machine learning in precision and genomic medicine.

Medical oncology (Northwood, London, England)
The advancement of precision medicine in medical care has led behind the conventional symptom-driven treatment process by allowing early risk prediction of disease through improved diagnostics and customization of more effective treatments. It is nec...

Precision medicine using patient-specific modelling: state of the art and perspectives in dental practice.

Clinical oral investigations
The dental practice has largely evolved in the last 50 years following a better understanding of the biomechanical behaviour of teeth and its supporting structures, as well as developments in the fields of imaging and biomaterials. However, many pati...