AIMC Topic: Glycosyltransferases

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Sweat Proteomics in Cystic Fibrosis: Discovering Companion Biomarkers for Precision Medicine and Therapeutic Development.

Cells Jul 31, 2022
In clinical routine, the diagnosis of cystic fibrosis (CF) is still challenging regardless of international consensus on diagnosis guidelines and tests. For decades, the classical Gibson and Cooke test measuring sweat chloride concentration has been ...
Humans Biomarkers Precision Medicine Proteomics Proteome Cystic Fibrosis Chlorides Sweat Cystic Fibrosis Transmembrane Conductance Regulator Glycosyltransferases
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Mapping the glycosyltransferase fold landscape using interpretable deep learning.

Nature communications Sep 27, 2021
Glycosyltransferases (GTs) play fundamental roles in nearly all cellular processes through the biosynthesis of complex carbohydrates and glycosylation of diverse protein and small molecule substrates. The extensive structural and functional diversifi...
Deep Learning Computational Biology Glycosylation Databases, Genetic Amino Acid Sequence Datasets as Topic Protein Structure, Secondary Protein Folding Sequence Alignment Protein Structure, Tertiary Glycosyltransferases
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A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.

PLoS computational biology Apr 7, 2016
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing Ga...
Humans Computer Simulation Animals Computational Biology Glycosylation Protein Processing, Post-Translational CHO Cells Cricetulus Metabolic Networks and Pathways Models, Biological Polysaccharides Knowledge Bases Mucins Terminology as Topic Gene Knockout Techniques Glycosyltransferases Genetic Engineering
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Glycosyltransferases in human milk oligosaccharide synthesis: structural mechanisms and rational design.

Current opinion in biotechnology Jun 1, 2025
Human milk oligosaccharides (HMOs) play a pivotal role in infant health through their multifunctional bioactive properties. Recent advances in synthetic biology have revolutionized microbial platforms for HMO biosynthesis, with glycosyltransferases (...
Humans Milk, Human Glycosylation Oligosaccharides Protein Engineering Glycosyltransferases
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