Despite decades of research, the successful clinical translation of intravenously administered nanomedicines is underwhelming. One significant barrier to progress is the opsonization and rapid clearance from the bloodstream due to protein corona form...
Journal of controlled release : official journal of the Controlled Release Society
Nov 20, 2025
'Character is destiny' holds apt resonance in determining the biofate of nanocarriers, where the formation of biomolecular or protein corona (PC) around nanocarriers bestows a "new biological identity" different from their synthetic identity. The acq...
Signature-based protein detection coupled with machine learning algorithms has revolutionized traditional sensing methods, providing rapid, inexpensive, and selectivity-driven detection without the use of specialized equipment. This strategy leverage...
Journal of the American Chemical Society
Oct 23, 2025
Aptamers are powerful synthetic recognition elements for biosensing, yet their application in complex biofluids, such as human serum, is critically limited by enzymatic degradation. To overcome this fundamental challenge, we introduce a novel analyti...
ConspectusEngineered nanomaterials (ENMs) have revolutionized biomedicine, energy, and environmental remediation due to their unique physicochemical properties. However, these properties are not static; they evolve dynamically as ENMs interact with r...
A comprehensive understanding of protein corona (PC) composition is critical for engineering nanoparticles (NPs) with optimal safety and therapeutic performance, because the PC governs NP pharmacokinetics, biodistribution, and cellular interactions. ...
This study investigates the feasibility of using tear sample analysis, based on protein corona formation on gold nanoparticles combined with electrospray ionization mass spectrometry (ESI-MS) and machine learning techniques, as a non-invasive approac...
International journal of pharmaceutics
Aug 19, 2025
Nanoparticles (NPs) represent critical roles both for drug delivery systems and diagnostics. Nevertheless, due to interaction in a biological medium and specific consequences-like formation of protein corona (PC), changes may happen that have influen...
As nanomaterials increasingly interact with complex biological environments, understanding and designing their interfacial layers is critical for enabling functional and responsive behaviors. The protein corona, a spontaneously formed biomolecular la...
Advances in colloid and interface science
Apr 30, 2025
The intricate interplay between nanomaterials and the biological molecules has garnered considerable interest in understanding the dynamics of protein corona formation at the nano-bio interface. This review provides an in-depth exploration of protein...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.