AIMC Topic: Proto-Oncogene Proteins c-abl

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Using machine learning to dissect host kinases required for Leishmania internalization and development.

Molecular and biochemical parasitology Aug 22, 2024
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages)...
Humans Machine Learning Macrophages Animals Mice Protein-Tyrosine Kinases Phagocytosis Protein Kinase Inhibitors Receptors, IgG Leishmaniasis Leishmania Host-Parasite Interactions Proto-Oncogene Proteins c-abl src-Family Kinases Leishmania mexicana
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Molecular insights on ABL kinase activation using tree-based machine learning models and molecular docking.

Molecular diversity Jun 30, 2021
Abelson kinase (c-Abl) is a non-receptor tyrosine kinase involved in several biological processes essential for cell differentiation, migration, proliferation, and survival. This enzyme's activation might be an alternative strategy for treating disea...
Humans Machine Learning Molecular Docking Simulation Drug Design Protein Binding Molecular Structure Molecular Dynamics Simulation Ligands Quantitative Structure-Activity Relationship Protein Kinase Inhibitors Binding Sites Proto-Oncogene Proteins c-abl
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