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Proto-Oncogene Proteins c-abl

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Molecular insights on ABL kinase activation using tree-based machine learning models and molecular docking.

Molecular diversity
Abelson kinase (c-Abl) is a non-receptor tyrosine kinase involved in several biological processes essential for cell differentiation, migration, proliferation, and survival. This enzyme's activation might be an alternative strategy for treating disea...

Using machine learning to dissect host kinases required for Leishmania internalization and development.

Molecular and biochemical parasitology
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages)...