AIMC Topic: Protein-Tyrosine Kinases

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Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression.

Frontiers in immunology Dec 17, 2024
INTRODUCTION: Osteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses. A greater understanding of the t...
Cell Line, Tumor Tumor Microenvironment Biomarkers, Tumor Osteosarcoma Gene Expression Regulation, Neoplastic Male Humans Bone Neoplasms Cell Proliferation Disease Progression Machine Learning Lymphocytes, Tumor-Infiltrating Prognosis Female Protein-Tyrosine Kinases DNA Copy Number Variations Protein Serine-Threonine Kinases
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Wee1 inhibitor optimization through deep-learning-driven decision making.

European journal of medicinal chemistry Sep 29, 2024
Deep learning has gained increasing attention in recent years, yielding promising results in hit screening and molecular optimization. Herein, we employed an efficient strategy based on multiple deep learning techniques to optimize Wee1 inhibitors, w...
Humans Antineoplastic Agents Deep Learning Cell Line, Tumor Cell Proliferation Structure-Activity Relationship Molecular Structure Protein Kinase Inhibitors Cell Cycle Proteins Dose-Response Relationship, Drug Protein-Tyrosine Kinases Decision Making Drug Screening Assays, Antitumor
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Using machine learning to dissect host kinases required for Leishmania internalization and development.

Molecular and biochemical parasitology Aug 22, 2024
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages)...
Protein Kinase Inhibitors Receptors, IgG Leishmaniasis Leishmania Animals Mice Protein-Tyrosine Kinases Phagocytosis Host-Parasite Interactions Proto-Oncogene Proteins c-abl src-Family Kinases Leishmania mexicana Humans Machine Learning Macrophages
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Naturally occurring caffeic acid phenethyl ester from chestnut honey-based propolis and virtual screening towards DYRK1A.

Natural product research Feb 1, 2024
Neurodegenerative diseases (NDDs) are disorders with dysfunction and ongoing loss of neurons, glial cells and the neural networks in the brain and spinal cord. DYRK1A protein was reported to modulate to the cytoskeletal fraction in human and mouse br...
Animals Molecular Docking Simulation Mice Protein-Tyrosine Kinases Humans Tandem Mass Spectrometry Protein Serine-Threonine Kinases Honey Propolis Molecular Structure Chromatography, High Pressure Liquid Caffeic Acids Dyrk Kinases Phenylethyl Alcohol
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Direct identification of ALK and ROS1 fusions in non-small cell lung cancer from hematoxylin and eosin-stained slides using deep learning algorithms.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Sep 3, 2022
Anaplastic lymphoma kinase (ALK) and ROS oncogene 1 (ROS1) gene fusions are well-established key players in non-small cell lung cancer (NSCLC). Although their frequency is relatively low, their detection is important for patient care and guides thera...
Proto-Oncogene Proteins Eosine Yellowish-(YS) Hematoxylin Anaplastic Lymphoma Kinase Gene Rearrangement Oncogene Proteins, Fusion Lung Neoplasms Carcinoma, Non-Small-Cell Lung Protein-Tyrosine Kinases In Situ Hybridization, Fluorescence Humans Deep Learning
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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

European journal of medicinal chemistry Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Arthritis, Rheumatoid Rats Cell Proliferation Rats, Sprague-Dawley Humans Animals Drug Design Mice Models, Molecular Pyrimidines Dose-Response Relationship, Drug Molecular Structure Dogs Agammaglobulinaemia Tyrosine Kinase Cell Line Haplorhini Microsomes, Liver Protein-Tyrosine Kinases Pyrroles Protein Kinase Inhibitors Structure-Activity Relationship
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Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1/TTK signaling pathway and structural insights in the NCI-60.

Computers in biology and medicine Jul 1, 2025
Ovarian cancer remains the third most prevalent and deadliest gynecologic malignancy worldwide, with most patients eventually developing resistance to platinum-based chemotherapy. This highlights a critical unmet need for innovative multitargeted the...
Protein Kinase Inhibitors Cell Cycle Proteins CDC2 Protein Kinase Humans Female Protein-Tyrosine Kinases Cell Line, Tumor Drug Discovery Protein Serine-Threonine Kinases Signal Transduction Antineoplastic Agents Ovarian Neoplasms
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AI-Driven Design and Development of Nontoxic DYRK1A Inhibitors.

Journal of medicinal chemistry May 22, 2025
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is implicated in several human diseases, including DYRK1A syndrome, cancer, and neurodegenerative disorders such as Alzheimer's disease, making it a relevant therapeutic target. I...
Drug Design Antioxidants Protein-Tyrosine Kinases Protein Serine-Threonine Kinases Protein Kinase Inhibitors Anti-Inflammatory Agents Humans Dyrk Kinases Quantitative Structure-Activity Relationship Neural Networks, Computer Artificial Intelligence Molecular Docking Simulation
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Clinical insights into hematologic malignancies and comparative analysis of molecular signatures of acute myeloid leukemia in different ethnicities using an artificial intelligence offering.

Medicine Dec 23, 2021
Next generation sequencing generates copious amounts of genomics data, causing manual interpretation to be laborious and non-scalable while remaining subjective (even for highly trained specialists). We evaluated the performance of the artificial int...
Off-Label Use fms-Like Tyrosine Kinase 3 Humans Hematologic Neoplasms Aged Leukemia, Myeloid, Acute Mutation Male Aged, 80 and over Artificial Intelligence Pharmaceutical Preparations Adolescent Middle Aged Young Adult Prognosis Ethnicity Protein-Tyrosine Kinases Adult Republic of Korea Female
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