AIMC Topic: Receptors, IgG

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Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning.

Frontiers in immunology Apr 15, 2025
INTRODUCTION: Aging is characterized by gradual structural and functional changes in the body over time, with intervertebral disc degeneration (IVDD) representing a key manifestation of spinal aging and a major contributor to low back pain (LBP).
Fas Ligand Protein Computational Biology Intervertebral Disc Degeneration Receptors, IgG Aging Middle Aged Gene Expression Profiling Humans Machine Learning Biomarkers Adult Male Female Aged
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Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis.

Mammalian genome : official journal of the International Mammalian Genome Society Feb 14, 2025
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide, and aberrant phagocytosis may be involved in its development. Understanding this aspect may provide new avenues for prompt CAD diagnosis.
Databases, Genetic MicroRNAs Interleukin-1beta Polymorphism, Single Nucleotide Computational Biology Transcription Factors Toll-Like Receptor 2 Syk Kinase Coronary Artery Disease Phagocytosis Receptors, IgG Humans Machine Learning Protein Interaction Maps Gene Regulatory Networks Biomarkers Gene Expression Profiling
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Using machine learning to dissect host kinases required for Leishmania internalization and development.

Molecular and biochemical parasitology Aug 22, 2024
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages)...
Macrophages Animals Mice Protein Kinase Inhibitors Receptors, IgG Protein-Tyrosine Kinases Phagocytosis Humans Machine Learning Proto-Oncogene Proteins c-abl src-Family Kinases Leishmaniasis Leishmania mexicana Leishmania Host-Parasite Interactions
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Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals.

Human vaccines & immunotherapeutics Dec 1, 2025
Despite over 13 billion SARS-CoV-2 vaccine doses administered globally, persistent post-vaccination symptoms, termed post-COVID-19 vaccine syndrome (PCVS), resemble post-acute sequelae of COVID-19 (PASC). Symptoms like cardiac, vascular, and neurolog...
SARS-CoV-2 Aged Adult COVID-19 Cytokines Humans Female Spike Glycoprotein, Coronavirus Male GPI-Linked Proteins Monocytes Receptors, IgG Middle Aged COVID-19 Vaccines
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Identification and validation of tissue-based gene biomarkers for acute intestinal graft-versus-host disease(AIGVHD).

Frontiers in immunology Jan 1, 2025
BACKGROUND: Acute intestinal graft-versus-host disease (AIGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (allo HSCT) with a high mortality rate. The primary aim of the present study is to identify tissue-based ge...
Humans Machine Learning Acute Disease Genetic Markers Mice Graft vs Host Disease Receptors, IgG Membrane Proteins Disease Models, Animal Hematopoietic Stem Cell Transplantation Biomarkers Intestinal Diseases Animals Gene Expression Profiling
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Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn's Disease.

Inflammatory bowel diseases Dec 19, 2017
BACKGROUND: In a pilot study, neutrophil CD64 surface expression was significantly elevated in newly diagnosed, pediatric-onset Crohn's disease. We aimed to test the CD64 biomarkers (neutrophil CD64 surface expression and soluble CD64) as determinate...
Crohn Disease Severity of Illness Index Young Adult Humans Child, Preschool Adult Case-Control Studies Biomarkers Receptors, IgG Child Inflammation Male Adolescent Pilot Projects Female Neutrophils Cohort Studies Intestinal Mucosa
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[Analysis of Cases with Elevated Blood (1->3)-β-D-glucan in Relation to an Infection Marker, Neutrophil CD64 Expression].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases Nov 1, 2015
(1->3)-β-D-glucan (BDG) is a constituent of the fungal cell wall and its blood level is known as a marker of fungal infection including pneumocystis pneumonia (PCP). Meanwhile, peripheral blood neutrophil CD64 expression (CD64) is upregulated in vari...
Pneumonia, Pneumocystis Humans beta-Glucans Mycoses Receptors, IgG Adult Biomarkers Middle Aged Male Female Neutrophils Aged
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