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Recombinases

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Prediction of designer-recombinases for DNA editing with generative deep learning.

Nature communications
Site-specific tyrosine-type recombinases are effective tools for genome engineering, with the first engineered variants having demonstrated therapeutic potential. So far, adaptation to new DNA target site selectivity of designer-recombinases has been...

DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning.

Journal of visualized experiments : JoVE
We report a fast, easy-to-implement, highly sensitive, sequence-specific, and point-of-care (POC) DNA virus detection system, which combines recombinase polymerase amplification (RPA) and CRISPR/Cas12a system for trace detection of DNA viruses. Targe...