AIMC Topic: DNA, Viral
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Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection.
Frontiers in cellular and infection microbiology
Jan 7, 2025
BACKGROUND: The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis ...
Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.
eLife
Sep 9, 2024
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we applied machine learning (ML) approaches to cross-...
Development, Validation, and Implementation of an Augmented Multiwell, Multitarget Quantitative PCR for the Analysis of Human Papillomavirus Genotyping through Software Automation, Data Science, and Artificial Intelligence.
The Journal of molecular diagnostics : JMD
Jul 5, 2024
The value of human papillomavirus (HPV) testing for cervical cancer screening is well established; however, its use as a primary screening option or as a reflex test after atypical cytology results is now gaining wider acceptance. The importance of f...
Assessment and classification of COVID-19 DNA sequence using pairwise features concatenation from multi-transformer and deep features with machine learning models.
SLAS technology
May 23, 2024
The 2019 novel coronavirus (renamed SARS-CoV-2, and generally referred to as the COVID-19 virus) has spread to 184 countries with over 1.5 million confirmed cases. Such a major viral outbreak demands early elucidation of taxonomic classification and ...
DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning.
Journal of visualized experiments : JoVE
May 10, 2024
We report a fast, easy-to-implement, highly sensitive, sequence-specific, and point-of-care (POC) DNA virus detection system, which combines recombinase polymerase amplification (RPA) and CRISPR/Cas12a system for trace detection of DNA viruses. Targe...
Clinical cure induced by pegylated interferon α-2b in the advantaged population of chronic hepatitis B virus infection: a retrospective cohort study.
Frontiers in cellular and infection microbiology
Jan 16, 2024
BACKGROUND: Among the advantaged population with clinical cure of chronic hepatitis B, chronic inactive hepatitis B virus carriers (IHCs) and nucleoside analog-experienced patients have similar serological manifestations. This study established non-i...
Serological and Molecular Characterization of Occult HBV Infection in Blood Donors from South Italy.
Viruses
Dec 31, 2023
Despite good vaccine coverage and careful blood donor selection policies, hepatitis B virus (HBV) is still the most frequent viral infection among blood donors (BDs) in Italy, mostly in the occult form (OBI). We studied the virological features of OB...
NGS read classification using AI.
PloS one
Dec 22, 2021
Clinical metagenomics is a powerful diagnostic tool, as it offers an open view into all DNA in a patient's sample. This allows the detection of pathogens that would slip through the cracks of classical specific assays. However, due to this unspecific...
The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy.
BMC cancer
Nov 5, 2021
BACKGROUND: Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has been related to the immunotherap...
Kaplan-Meier Estimate
Papillomaviridae
Oncogenic Viruses
Genetic Variation
High-Throughput Nucleotide Sequencing
Genome, Viral
Tumor Virus Infections
Squamous Cell Carcinoma of Head and Neck
Head and Neck Neoplasms
Support Vector Machine
DNA, Viral
Transcriptome
Epstein-Barr Virus Infections
RNA-Seq
Herpesvirus 4, Human
Immunotherapy
Mutation
Stomach Neoplasms
Papillomavirus Infections
Leukocytes
Tumor Microenvironment
Biomarkers, Tumor
Neoplasms
Humans
Machine Learning
A Deep Learning-Based Method for Identification of Bacteriophage-Host Interaction.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2021
Multi-drug resistance (MDR) has become one of the greatest threats to human health worldwide, and novel treatment methods of infections caused by MDR bacteria are urgently needed. Phage therapy is a promising alternative to solve this problem, to whi...
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