AIMC Topic: Recombinational DNA Repair

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Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images.

Cell reports. Medicine Dec 13, 2022
Homologous recombination DNA-repair deficiency (HRD) is becoming a well-recognized marker of platinum salt and polyADP-ribose polymerase inhibitor chemotherapies in ovarian and breast cancers. While large-scale screening for HRD using genomic markers...
Humans Biomarkers, Tumor Neoplasms Deep Learning Recombinational DNA Repair
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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning.

Nature biomedical engineering Apr 15, 2021
The optimization of therapeutic antibodies is time-intensive and resource-demanding, largely because of the low-throughput screening of full-length antibodies (approximately 1 × 10 variants) expressed in mammalian cells, which typically results in fe...
Humans Animals Deep Learning Protein Binding CRISPR-Cas Systems Amino Acid Sequence Antibody Specificity Receptor, ErbB-2 Trastuzumab Antigens Hybridomas Mutagenesis, Site-Directed Protein Engineering Antibody Affinity Sequence Analysis, Protein Recombinational DNA Repair
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