AIMC Topic: Rhodopsin

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RhoMax: Computational Prediction of Rhodopsin Absorption Maxima Using Geometric Deep Learning.

Journal of chemical information and modeling Jun 3, 2024
Microbial rhodopsins (MRs) are a diverse and abundant family of photoactive membrane proteins that serve as model systems for biophysical techniques. Optogenetics utilizes genetic engineering to insert specialized proteins into specific neurons or br...
Deep Learning Models, Molecular Amino Acid Sequence Protein Conformation Optogenetics Rhodopsin Rhodopsins, Microbial
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Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks.

Proceedings of the National Academy of Sciences of the United States of America Mar 15, 2018
Network oscillations across and within brain areas are critical for learning and performance of memory tasks. While a large amount of work has focused on the generation of neural oscillations, their effect on neuronal populations' spiking activity an...
Neural Networks, Computer Computer Simulation Learning Animals Mice Models, Neurological Action Potentials Neurons Nerve Net Ion Channels Rhodopsin
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Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

PLoS computational biology Oct 23, 2017
There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilay...
Humans Machine Learning Drug Design Structure-Activity Relationship HEK293 Cells Cell Membrane Lipid Bilayers Sequence Analysis, Protein Ion Channels Subcellular Fractions Rhodopsin
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