AIMC Topic: Optogenetics

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Optogenetic neural spheroids excite primary neural network.

Journal of neural engineering Jun 26, 2025
Optical stimulation ofneurons requires prior transfection with light gated ion channels. This additional step brings complexity and requires optimization. Simplification of the process will ease the undertaking of studies on biological neural network...
Optogenetics Embryonic Stem Cells Cells, Cultured Animals Nerve Net Spheroids, Cellular Mice Neurons
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A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the ventral nerve cord.

eLife Jun 10, 2025
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due t...
Animals Transcription Factors Neurons Drosophila Proteins Optogenetics Gene Library Behavior, Animal Cell Lineage Drosophila melanogaster Drosophila Nerve Net
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Parvalbumin neurons and cortical coding of dynamic stimuli: a network model.

Journal of neurophysiology May 13, 2025
Cortical circuits feature both excitatory and inhibitory cells that underlie the encoding of dynamic sensory stimuli, e.g., speech, music, odors, and natural scenes. Although previous studies have shown that inhibition plays an important role in shap...
Animals Nerve Net Mice Neuronal Plasticity Action Potentials Auditory Perception Optogenetics Neural Networks, Computer Models, Neurological Neurons Parvalbumins Auditory Cortex
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The fruit fly, , as a microrobotics platform.

Proceedings of the National Academy of Sciences of the United States of America Apr 8, 2025
Engineering small autonomous agents capable of operating in the microscale environment remains a key challenge, with current systems still evolving. Our study explores the fruit fly, , a classic model system in biology and a species adept at microsca...
Robotics Smell Behavior, Animal Locomotion Animals Drosophila melanogaster Optogenetics Mushroom Bodies
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A deep learning strategy to identify cell types across species from high-density extracellular recordings.

Cell Feb 28, 2025
High-density probes allow electrophysiological recordings from many neurons simultaneously across entire brain circuits but fail to reveal cell type. Here, we develop a strategy to identify cell types from extracellular recordings in awake animals an...
Optogenetics Purkinje Cells Deep Learning Mice Rats Cerebellum Interneurons Mice, Inbred C57BL Animals Neurons Male
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Decoding neuronal networks: A Reservoir Computing approach for predicting connectivity and functionality.

Neural networks : the official journal of the International Neural Network Society Dec 26, 2024
In this study, we address the challenge of analyzing electrophysiological measurements in neuronal networks. Our computational model, based on the Reservoir Computing Network (RCN) architecture, deciphers spatio-temporal data obtained from electrophy...
Algorithms Computer Simulation Neural Networks, Computer Nerve Net Optogenetics Animals Models, Neurological Neurons
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Extending visual range of bacteria with upconversion nanoparticles and constructing NIR-responsive bio-microrobots.

Journal of colloid and interface science Dec 1, 2024
The motility of bacteria is crucial for navigating competitive environments and is closely linked to physiological activities essential for their survival, such as biofilm development. Precise regulation of bacterial motility enhances our understandi...
Methyl-Accepting Chemotaxis Proteins Infrared Rays Neoplasms Spheroids, Cellular Cell Line, Tumor Optogenetics Nanoparticles Bacterial Proteins Humans Escherichia coli Gene Expression Regulation Drug Delivery Systems Robotics
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RhoMax: Computational Prediction of Rhodopsin Absorption Maxima Using Geometric Deep Learning.

Journal of chemical information and modeling Jun 3, 2024
Microbial rhodopsins (MRs) are a diverse and abundant family of photoactive membrane proteins that serve as model systems for biophysical techniques. Optogenetics utilizes genetic engineering to insert specialized proteins into specific neurons or br...
Protein Conformation Optogenetics Rhodopsin Rhodopsins, Microbial Deep Learning Models, Molecular Amino Acid Sequence
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An Optogenetics-Inspired Flexible van der Waals Optoelectronic Synapse and its Application to a Convolutional Neural Network.

Advanced materials (Deerfield Beach, Fla.) Aug 22, 2021
Optogenetics refers to a technique that uses light to modulate neuronal activity with a high spatiotemporal resolution, which enables the manipulation of learning and memory functions in the human brain. This strategy of controlling neuronal activity...
Electric Conductivity Optogenetics Rhenium Electronics Neural Networks, Computer Sulfides Biomimetics Light Synapses
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Spine dynamics in the brain, mental disorders and artificial neural networks.

Nature reviews. Neuroscience May 28, 2021
In the brain, most synapses are formed on minute protrusions known as dendritic spines. Unlike their artificial intelligence counterparts, spines are not merely tuneable memory elements: they also embody algorithms that implement the brain's ability ...
Optogenetics Brain Machine Learning Animals Receptors, Dopamine Species Specificity Mental Processes Humans Algorithms Reward Neuronal Plasticity Neurotransmitter Agents Mental Disorders Models, Neurological Dopamine Neural Networks, Computer Synapses Artificial Intelligence Memory, Short-Term Dendritic Spines
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