AIMC Topic: Signal Transduction

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Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Radiation-Sensitizing Agents Antineoplastic Combined Chemotherapy Protocols Iodine Radioisotopes Apoptosis Blotting, Western Poly(ADP-ribose) Polymerases Drug Synergism Flow Cytometry Burkitt Lymphoma Cell Proliferation Radiopharmaceuticals Tumor Cells, Cultured Humans Doxorubicin Signal Transduction Rituximab RNA, Messenger
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Mining Gene Regulatory Networks by Neural Modeling of Expression Time-Series.

IEEE/ACM transactions on computational biology and bioinformatics Jan 1, 2015
Discovering gene regulatory networks from data is one of the most studied topics in recent years. Neural networks can be successfully used to infer an underlying gene network by modeling expression profiles as times series. This work proposes a novel...
Animals Gene Expression Profiling Neural Networks, Computer Algorithms Humans Data Mining Pattern Recognition, Automated Proteome Gene Expression Regulation Signal Transduction
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Fuzzy Logic as a Computational Tool for Quantitative Modelling of Biological Systems with Uncertain Kinetic Data.

IEEE/ACM transactions on computational biology and bioinformatics Jan 1, 2015
Quantitative modelling of biological systems has become an indispensable computational approach in the design of novel and analysis of existing biological systems. However, kinetic data that describe the system's dynamics need to be known in order to...
Humans Animals Gene Expression Profiling Kinetics Models, Biological Protein Interaction Mapping Fuzzy Logic Models, Statistical Proteome Signal Transduction
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An effective fuzzy kernel clustering analysis approach for gene expression data.

Bio-medical materials and engineering Jan 1, 2015
Fuzzy clustering is an important tool for analyzing microarray data. A major problem in applying fuzzy clustering method to microarray gene expression data is the choice of parameters with cluster number and centers. This paper proposes a new approac...
Animals Gene Expression Profiling Pattern Recognition, Automated Proteome Oligonucleotide Array Sequence Analysis Models, Biological Signal Transduction Humans Algorithms Fuzzy Logic Multigene Family Computer Simulation Models, Statistical
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P-Finder: Reconstruction of Signaling Networks from Protein-Protein Interactions and GO Annotations.

IEEE/ACM transactions on computational biology and bioinformatics Jan 1, 2015
Because most complex genetic diseases are caused by defects of cell signaling, illuminating a signaling cascade is essential for understanding their mechanisms. We present three novel computational algorithms to reconstruct signaling networks between...
Computational Biology Signal Transduction Algorithms Protein Interaction Maps Molecular Sequence Annotation Gene Ontology
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Meta-learning framework applied in bioinformatics inference system design.

International journal of data mining and bioinformatics Jan 1, 2015
This paper describes a meta-learner inference system development framework which is applied and tested in the implementation of bioinformatic inference systems. These inference systems are used for the systematic classification of the best candidates...
Bacterial Proteins Models, Biological Pattern Recognition, Automated Sequence Analysis, Protein Metabolome Meta-Analysis as Topic Bacteria Signal Transduction Algorithms Computer Simulation Artificial Intelligence
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