AIMC Topic: Poly(ADP-ribose) Polymerases

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Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies.

International journal of environmental research and public health Mar 20, 2020
Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to their highly invasive nature and relatively low response to therapeutics...
Humans Artificial Intelligence Female Triple Negative Breast Neoplasms Signal Transduction Neoplasm Recurrence, Local Poly(ADP-ribose) Polymerases Poly(ADP-ribose) Polymerase Inhibitors Receptors, Cell Surface
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PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues - A population pharmacokinetic/pharmacodynamic analysis of rucaparib.

Clinical pharmacology in drug development Jan 26, 2015
PURPOSE: Rucaparib is a potent Poly (ADP-ribose) Polymerase (PARP) inhibitor currently under clinical development. The objectives of this analysis were to establish population PK and PK/PD models for rucaparib, and to evaluate the predictability of P...
Humans Biomarkers Computer Simulation Neoplasms Infusions, Intravenous Models, Biological Lymphocytes Indoles Drug Administration Schedule Poly(ADP-ribose) Polymerases Poly(ADP-ribose) Polymerase Inhibitors
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Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To identify the active anti-tumor constituents in the extract from Danshen (Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions.
Humans Cell Line, Tumor Cell Proliferation Apoptosis Caspase 3 Antineoplastic Agents, Phytogenic Drugs, Chinese Herbal Abietanes Poly(ADP-ribose) Polymerases Salvia miltiorrhiza
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Doxorubicin enhances (131)I-rituximab induced cell death in Raji cells.

Journal of cancer research and therapeutics Jan 1, 2015
AIM: There are various therapeutic modalities of treatment for non-Hodgkin's lymphoma, but with certain limitations, hence, investigating the scope of combined therapeutic approach.
Humans RNA, Messenger Cell Proliferation Signal Transduction Antineoplastic Combined Chemotherapy Protocols Apoptosis Blotting, Western Flow Cytometry Radiopharmaceuticals Doxorubicin Iodine Radioisotopes Drug Synergism Tumor Cells, Cultured Rituximab Poly(ADP-ribose) Polymerases Burkitt Lymphoma Radiation-Sensitizing Agents
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