AIMC Topic: Smad2 Protein

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Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar.

International wound journal Nov 20, 2023
Hypertrophic scar (HS) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. We analysed scRNA-seq data from samples of normal sk...
Humans Machine Learning Female Male Gene Expression Profiling Signal Transduction Fibroblasts Transforming Growth Factor beta1 Smad3 Protein Smad2 Protein Cicatrix, Hypertrophic Thrombospondins
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Deep learning for de-convolution of Smad2 versus Smad3 binding sites.

BMC genomics Jul 20, 2022
BACKGROUND: The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory tar...
Deep Learning Signal Transduction Cell Line Transforming Growth Factor beta Smad3 Protein Binding Sites Smad2 Protein
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Effect of doxycycline on transforming growth factor-beta-1-induced matrix metalloproteinase 2 expression, migration, and collagen contraction in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: It is well known that doxycycline has antibacterial and anti-inflammatory effects. In this study, we aimed to investigate the effects of doxycycline on the transforming growth factor (TGF) beta 1-induced matrix metalloproteinase (MMP) 2 expr...
Humans Cells, Cultured Female Young Adult Adult Male Signal Transduction Cell Movement Fibroblasts Nasal Polyps Cell Differentiation Transforming Growth Factor beta1 Matrix Metalloproteinase 2 Collagen Gene Expression Regulation Doxycycline Smad2 Protein
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