AIMC Topic: Smad3 Protein

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Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia.

BMC cancer Feb 15, 2025
BACKGROUND: Dysregulation or abnormality of the programmed cell death (PCD) pathway is closely related to the occurrence and development of many tumors, including acute myeloid leukemia (AML). Studying the abnormal characteristics of PCD pathway-rela...
Humans Machine Learning Prognosis Female Biomarkers, Tumor Leukemia, Myeloid, Acute Male Middle Aged Gene Expression Profiling Transcriptome Nomograms Apoptosis Smad3 Protein
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Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar.

International wound journal Nov 20, 2023
Hypertrophic scar (HS) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. We analysed scRNA-seq data from samples of normal sk...
Humans Machine Learning Female Male Gene Expression Profiling Signal Transduction Fibroblasts Transforming Growth Factor beta1 Smad3 Protein Smad2 Protein Cicatrix, Hypertrophic Thrombospondins
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Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis.

Journal of environmental sciences (China) Jul 29, 2023
Epidemiological evidence presents that dust storms are related to respiratory diseases, such as pulmonary fibrosis (PF). However, the precise underlying mechanisms of SPM-elicited adverse effects still need to be investigated. Epithelial-mesenchymal ...
Humans Reactive Oxygen Species Epithelial Cells Interleukin-8 Particulate Matter Pulmonary Fibrosis Epithelial-Mesenchymal Transition Transforming Growth Factor beta1 Alveolar Epithelial Cells Smad3 Protein
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Deep learning for de-convolution of Smad2 versus Smad3 binding sites.

BMC genomics Jul 20, 2022
BACKGROUND: The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory tar...
Deep Learning Signal Transduction Cell Line Transforming Growth Factor beta Smad3 Protein Binding Sites Smad2 Protein
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