AIMC Topic: Staphylococcal Protein A
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Computer-aided design space identification for screening of protein A affinity chromatography resins.
Journal of chromatography. A
Apr 8, 2024
The rapidly growing market of monoclonal antibodies (mAbs) within the biopharmaceutical industry has incentivised numerous works on the design of more efficient production processes. Protein A affinity chromatography is regarded as one of the best pr...
Basis for Accurate Protein p Prediction with Machine Learning.
Journal of chemical information and modeling
May 5, 2023
pH regulates protein structures and the associated functions in many biological processes via protonation and deprotonation of ionizable side chains where the titration equilibria are determined by p's. To accelerate pH-dependent molecular mechanism ...
Comparison of UV- and Raman-based monitoring of the Protein A load phase and evaluation of data fusion by PLS models and CNNs.
Biotechnology and bioengineering
Aug 8, 2021
A promising application of Process Analytical Technology to the downstream process of monoclonal antibodies (mAbs) is the monitoring of the Protein A load phase as its control promises economic benefits. Different spectroscopic techniques have been e...
A robust robotic high-throughput antibody purification platform.
Journal of chromatography. A
May 24, 2016
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from w...
Explainable deep learning enhances robust and reliable real-time monitoring of a chromatographic protein A capture step.
Biotechnology journal
Jan 1, 2024
The application of model-based real-time monitoring in biopharmaceutical production is a major step toward quality-by-design and the fundament for model predictive control. Data-driven models have proven to be a viable option to model bioprocesses. I...
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