AIMC Topic: Chromatography, Affinity

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Hollow polydopamine for the enhanced ultrasensitive dual-modal immunochromatographic detection of Salmonella typhimurium in dairy products via machine learning.

Mikrochimica acta
Salmonella typhimurium (S. typhimurium) A dual-mode colorimetric/photothermal immunochromatographic strip (ICS) employing hollow polydopamine nanoparticles (h-PDA) is reported for the ultrasensitive detection of Salmonella typhimurium (S. typhimurium...

Machine learning enhanced process design in protein a chromatography.

Journal of chromatography. A
Quality by Digital Design (QbDD) employs in-silico experimentation to reduce wet-lab reliance and accelerate development. Design space identification is critical for QbDD to overcome bottlenecks and streamline process design. Traditional design space...

Collaborative Internal Cavity Effect and Interfacial Modulation Mechanism for Boosting Deep Learning-Powered Immunochromatographic Pathogen Detection.

Analytical chemistry
Nanoenabled immunochromatographic assay (ICA) emerges as a powerful tool for pathogen diagnosis, yet current nanotechnologies are still constrained by inadequate light-matter interaction efficiency, sluggish nanomaterial flow dynamics, and inefficien...

Dual-Channel Catalytic Immunochromatography Empowered by Machine Learning: Ultrasensitive Detection of O157:H7 via Magnetic CoFeO@HRP Nanocomposites.

Analytical chemistry
Traditional immunochromatographic test strips face significant limitations in detecting trace levels of O157:H7 due to insufficient sensitivity and reliability. To address this challenge, we developed a novel "three-In-One" nanoplatform based on mag...

A smartphone-integrated deep learning strategy-assisted rapid detection system for monitoring dual-modal immunochromatographic assay.

Talanta
This study focuses on the integration of a custom-built and optimally trained YOLO v5 model into a smartphone app developed with Java language. A dual-modal immunochromatographic rapid detection system based on a deep learning strategy for smartphone...

A Fluorescent Immunochromatography Test Strip for the Rapid Identification of SVV and FMDV.

Transboundary and emerging diseases
Seneca Valley virus (SVV) and foot-and-mouth disease virus (FMDV) belong to the Picornaviridae family, which can cause similar symptoms. After infection, pigs will develop fever; loss of appetite; blister lesions on the skin and mucous membrane of th...

Computer-aided design space identification for screening of protein A affinity chromatography resins.

Journal of chromatography. A
The rapidly growing market of monoclonal antibodies (mAbs) within the biopharmaceutical industry has incentivised numerous works on the design of more efficient production processes. Protein A affinity chromatography is regarded as one of the best pr...

Aptamer facilitated purification of functional proteins.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
DNA aptamers are attractive capture probes for affinity chromatography since, in contrast to antibodies, they can be chemically synthesized and, in contrast to tag-specific capture probes (such as Nickel-NTA or Glutathione), they can be used for puri...

Use of quantum dot beads-labeled monoclonal antibody to improve the sensitivity of a quantitative and simultaneous immunochromatographic assay for neuron specific enolase and carcinoembryonic antigen.

Talanta
Detection of multiplex tumor markers was of great importance for cancer diagnosis. Immunochromatographic test strip (ICTS) was the most frequently-used point-of-care detection means. Herein, a convenient and fast method for simultaneous quantitative ...

A robust robotic high-throughput antibody purification platform.

Journal of chromatography. A
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from w...