AIMC Topic: Chromatography, Gel
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An automated, low volume, and high-throughput analytical platform for aggregate quantitation from cell culture media.
Journal of chromatography. A
Jan 21, 2023
High throughput screening methods have driven a paradigm shift in biopharmaceutical development by reducing the costs of good manufactured (COGM) and accelerate the launch to market of novel drug products. Scale-down cell culture systems such as shak...
PCprophet: a framework for protein complex prediction and differential analysis using proteomic data.
Nature methods
Apr 15, 2021
Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. Approaches based on biochemical fractionation of intact, native complexes and correlation of protein ...
Extraction optimization, purification and characterization of polysaccharides from the seed coat of black soybean.
PloS one
Dec 21, 2017
In this study, the extraction of water-soluble polysaccharides from the seed coat of black soybean (BSCP) was investigated and optimized. A response surface methodology based on a Box-Behnken design (BBD) was used to optimize the extraction condition...
Stability of infliximab solutions in different temperature and dilution conditions.
Journal of pharmaceutical and biomedical analysis
Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Peptide Mapping
Pharmaceutical Solutions
Infliximab
Chromatography, Ion Exchange
Technology, Pharmaceutical
Biosimilar Pharmaceuticals
Nephelometry and Turbidimetry
Drug Compounding
Protein Stability
Osmolar Concentration
Nanoparticles
Drug Stability
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Antirheumatic Agents
Temperature
Chromatography, Gel
Protein Aggregates
Time Factors
A robust robotic high-throughput antibody purification platform.
Journal of chromatography. A
May 24, 2016
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from w...
Determination of residual dextran sulfate in protein products by SEC-HPLC.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 23, 2015
Dextran sulfate is a polyanionic derivative of dextran, produced by esterification of dextran with chlorosulphonic acid. Dextran sulfate with an average molecular weight of 8000Da can be added to the cell culture to inhibit binding of proteins to cel...
[GPC Fingerprint Chromatograms of Aloe vera Leaf Gel Polysaccharides].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Oct 1, 2015
OBJECTIVE: To establish the gel permeation chromatography (GPC) fingerprint chromatograms of polysaccharides in Aloe vera leaf gel from the same habitat (Beijing) and different habitats for evaluating the quality of Aloe vera leaf gel products commer...
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