AIMC Topic: Synthetic Biology

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Integrating Deep Learning and Synthetic Biology: A Co-Design Approach for Enhancing Gene Expression via N-Terminal Coding Sequences.

ACS synthetic biology
N-terminal coding sequence (NCS) influences gene expression by impacting the translation initiation rate. The NCS optimization problem is to find an NCS that maximizes gene expression. The problem is important in genetic engineering. However, current...

AI-Assisted Rational Design and Activity Prediction of Biological Elements for Optimizing Transcription-Factor-Based Biosensors.

Molecules (Basel, Switzerland)
The rational design, activity prediction, and adaptive application of biological elements (bio-elements) are crucial research fields in synthetic biology. Currently, a major challenge in the field is efficiently designing desired bio-elements and acc...

Artificial Intelligence Methods and Models for Retro-Biosynthesis: A Scoping Review.

ACS synthetic biology
Retrosynthesis aims to efficiently plan the synthesis of desirable chemicals by strategically breaking down molecules into readily available building block compounds. Having a long history in chemistry, retro-biosynthesis has also been used in the fi...

Cell factory design with advanced metabolic modelling empowered by artificial intelligence.

Metabolic engineering
Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities for modern biotechnology. High-performance cell factories, the backbone of industrial biotechnology, are ultimately responsible for determining whether a b...

Machine learning for the advancement of genome-scale metabolic modeling.

Biotechnology advances
Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the interrelations between genotype, phenotype, and external environment. The recent advancement of high-throughput experimental approaches and multi-omics strategies...

Advancing microbial production through artificial intelligence-aided biology.

Biotechnology advances
Microbial cell factories (MCFs) have been leveraged to construct sustainable platforms for value-added compound production. To optimize metabolism and reach optimal productivity, synthetic biology has developed various genetic devices to engineer mic...

Synthetic biology advances towards a bio-based society in the era of artificial intelligence.

Current opinion in biotechnology
Synthetic biology is a rapidly emerging field with broad underlying applications in health, industry, agriculture, or environment, enabling sustainable solutions for unmet needs of modern society. With the very recent addition of artificial intellige...

Rational construction of synthetic consortia: Key considerations and model-based methods for guiding the development of a novel biosynthesis platform.

Biotechnology advances
The rapid development of synthetic biology has significantly improved the capabilities of mono-culture systems in converting different substrates into various value-added bio-chemicals through metabolic engineering. However, overexpression of biosynt...

Synthetic biological neural networks: From current implementations to future perspectives.

Bio Systems
Artificial neural networks, inspired by the biological networks of the human brain, have become game-changing computing models in modern computer science. Inspired by their wide scope of applications, synthetic biology strives to create their biologi...

Transforming drug development with synthetic biology and AI.

Trends in biotechnology
The COVID-19 pandemic has thrust RNA as a platform for drug development into the spotlight. However, identifying promising drug candidates is challenging. With advances in synthetic biology and artificial intelligence (AI) models, we can overcome thi...