AIMC Topic: Synthetic Biology
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Cell factory design with advanced metabolic modelling empowered by artificial intelligence.
Metabolic engineering
Jul 20, 2024
Advances in synthetic biology and artificial intelligence (AI) have provided new opportunities for modern biotechnology. High-performance cell factories, the backbone of industrial biotechnology, are ultimately responsible for determining whether a b...
Machine learning for the advancement of genome-scale metabolic modeling.
Biotechnology advances
Jun 27, 2024
Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the interrelations between genotype, phenotype, and external environment. The recent advancement of high-throughput experimental approaches and multi-omics strategies...
Advancing microbial production through artificial intelligence-aided biology.
Biotechnology advances
Jun 24, 2024
Microbial cell factories (MCFs) have been leveraged to construct sustainable platforms for value-added compound production. To optimize metabolism and reach optimal productivity, synthetic biology has developed various genetic devices to engineer mic...
Synthetic biology advances towards a bio-based society in the era of artificial intelligence.
Current opinion in biotechnology
May 22, 2024
Synthetic biology is a rapidly emerging field with broad underlying applications in health, industry, agriculture, or environment, enabling sustainable solutions for unmet needs of modern society. With the very recent addition of artificial intellige...
Rational construction of synthetic consortia: Key considerations and model-based methods for guiding the development of a novel biosynthesis platform.
Biotechnology advances
Mar 24, 2024
The rapid development of synthetic biology has significantly improved the capabilities of mono-culture systems in converting different substrates into various value-added bio-chemicals through metabolic engineering. However, overexpression of biosynt...
Synthetic biological neural networks: From current implementations to future perspectives.
Bio Systems
Feb 23, 2024
Artificial neural networks, inspired by the biological networks of the human brain, have become game-changing computing models in modern computer science. Inspired by their wide scope of applications, synthetic biology strives to create their biologi...
Transforming drug development with synthetic biology and AI.
Trends in biotechnology
Feb 20, 2024
The COVID-19 pandemic has thrust RNA as a platform for drug development into the spotlight. However, identifying promising drug candidates is challenging. With advances in synthetic biology and artificial intelligence (AI) models, we can overcome thi...
Cell-type-directed design of synthetic enhancers.
Nature
Dec 12, 2023
Transcriptional enhancers act as docking stations for combinations of transcription factors and thereby regulate spatiotemporal activation of their target genes. It has been a long-standing goal in the field to decode the regulatory logic of an enhan...
Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo.
Nature
Dec 12, 2023
Enhancers control gene expression and have crucial roles in development and homeostasis. However, the targeted de novo design of enhancers with tissue-specific activities has remained challenging. Here we combine deep learning and transfer learning t...
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