Journal of pharmaceutical and biomedical analysis
Jan 26, 2025
Near-infrared hyperspectral imaging (NIR-HSI) integrated with expert systems can support the monitoring of active pharmaceutical ingredients (APIs) and provide effective quality control of tablet formulations. However, existing quality control method...
International journal of pharmaceutics
Jan 18, 2025
Film-coating is a critical step in pharmaceutical manufacturing. Traditional visual inspections for film-coated tablet defect assessment are subjective, inefficient, and labor-intensive. We propose a novel approach utilizing machine learning and imag...
Drug development and industrial pharmacy
Dec 8, 2024
OBJECTIVE: The objective of this study is to create predictive models utilizing machine learning algorithms, including Artificial Neural Networks (ANN), k-nearest neighbor (kNN), support vector machines (SVM), and linear regression, to predict critic...
International journal of pharmaceutics
Dec 4, 2024
Development of materials by mixing different base components is a widespread methodology to create materials with improved properties compared to those of its base components. However, efficient determination of the properties of mixture-based materi...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Nov 28, 2024
This study proposes a novel non-linear modelling approach to predict the dissolution profiles of extended-release tablets, by combining a full-factorial design, curve fitting to the dissolution profiles, and artificial neural networks (ANN), with lin...
Pharmaceutical drug dosage forms are critical for ensuring the effective and safe delivery of active pharmaceutical ingredients to patients. However, traditional formulation development often relies on extensive lab and animal experimentation, which ...
International journal of pharmaceutics
Nov 1, 2024
This paper presents novel measurement methods, where deep learning was used to detect tableting defects and determine the crushing strength and disintegration time of tablets on images captured by machine vision. Five different classes of defects wer...
International journal of pharmaceutics
Oct 28, 2024
Roller compaction is a crucial unit operation in pharmaceutical manufacturing, with its ribbon porosity widely recognised as a critical quality attribute. Terahertz spectroscopy has emerged as a fast and non-destructive technique to measure porosity ...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Sep 19, 2024
The field of Machine Learning (ML) has garnered significant attention, particularly in healthcare for predicting disease severity. Recently, the pharmaceutical sector has also adopted ML techniques in various stages of drug development. Tablets are t...
International journal of pharmaceutics
Sep 16, 2024
The manufacturing of pharmaceutical solid dosage forms, such as tablets involves a large number of successive processing operations including crystallisation of the drug substance, granulation, drying, milling, mixing of the formulation, and compacti...
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