This study focuses on predicting the solubility of paracetamol and density of solvent using temperature (T) and pressure (P) as inputs. The process for production of the drug is supercritical technique in which the focus was on theoretical investigat...
Analytical methods : advancing methods and applications
Aug 21, 2025
Developing a convenient, accurate, and cost-effective analytical method for the detection of Cytochrome P450 (CYP) mediated drug bioactivation remains a challenge. The present study proposes a method using Raman spectroscopy (RS) combined with machin...
Physical chemistry chemical physics : PCCP
Jul 30, 2025
Acetaminophen ranks among the most widely used pharmaceutical and personal care products today. Following consumption, the drug and its metabolites are excreted into sewage systems, wastewater treatment plants, and various aquatic environments, leadi...
The development of new methods of identification of active pharmaceutical ingredients (API) is a subject of paramount importance for research centers, the pharmaceutical industry, and law enforcement agencies. Here, a system for identifying and class...
BACKGROUND: Acetaminophen (APAP) is commonly used as an antipyretic analgesic. However, acetaminophen overdose may contribute to liver injury and even liver failure. Acetaminophen-induced liver injury (AILI) is closely related to mitochondrial oxidat...
International journal of pharmaceutics
Apr 12, 2024
Personalized medicine aims to effectively and efficiently provide customized drugs that cater to diverse populations, which is a significant yet challenging task. Recently, the integration of artificial intelligence (AI) and three-dimensional (3D) pr...
Expert opinion on drug metabolism & toxicology
Jul 17, 2023
INTRODUCTION: Acute poisoning is a significant global health burden, and the causative agent is often unclear. The primary aim of this pilot study was to develop a deep learning algorithm that predicts the most probable agent a poisoned patient was e...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Sep 2, 2021
Spectrophotometric data analysis using multivariate approaches has many useful applications. One of these applications is the analysis of active ingredients in presence of impurities. Four chemometric-assisted spectrophotometric methods, namely, prin...
INTRODUCTION: Very little artificial intelligence (AI) work has been performed to investigate acetaminophen-associated hepatotoxicity. The objective of this study was to develop an AI algorithm for analyzing weighted features for toxic hepatitis afte...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May 16, 2020
Sinus and congestion mixture of three drugs and an impurity was studied for their spectral resolution using four multivariate algorithms. The studied drugs present in extremes of low and high concentrations. Low concentration levels of phenylephrine ...
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