AIMC Topic: Toll-Like Receptors

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Identification of CTSK as a TLR-related critical biomarker in liver cirrhosis via integrative bioinformatics and pathological characterization.

Scientific reports Jul 17, 2025
Liver cirrhosis (LC) is a common chronic disease worldwide with a poor prognosis, and its pathogenesis has not been fully elucidated. Toll-like receptors (TLRs) are crucial in LC progression. Here, we identified TLR-related genes, providing novel ins...
Humans Biomarkers Molecular Docking Simulation Gene Expression Profiling Gene Regulatory Networks Computational Biology Liver Cirrhosis Signal Transduction Gene Expression Regulation Toll-Like Receptors
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Toll-like receptor signaling in vertebrates: testing the integration of protein, complex, and pathway data in the protein ontology framework.

PloS one Apr 20, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation o...
Humans Animals Mice Computational Biology Chickens Signal Transduction Evolution, Molecular Biological Ontologies Protein Transport Molecular Sequence Annotation Toll-Like Receptors
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