AIMC Topic: Transition Temperature
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DeepDDG: Predicting the Stability Change of Protein Point Mutations Using Neural Networks.
Journal of chemical information and modeling
Feb 25, 2019
Accurately predicting changes in protein stability due to mutations is important for protein engineering and for understanding the functional consequences of missense mutations in proteins. We have developed DeepDDG, a neural network-based method, fo...
Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis.
Diagnostic microbiology and infectious disease
Dec 30, 2018
Pyrazinamide (PZA) is a key antibiotic for the treatment of drug susceptible tuberculosis. PZA-resistance is mainly mediated by mutations in the pncA gene; however the current gold standard is a phenotypic drug susceptibility test requiring a well-ad...
Convolutional Embedding of Attributed Molecular Graphs for Physical Property Prediction.
Journal of chemical information and modeling
Jul 25, 2017
The task of learning an expressive molecular representation is central to developing quantitative structure-activity and property relationships. Traditional approaches rely on group additivity rules, empirical measurements or parameters, or generatio...
In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning.
Journal of chemical information and modeling
Jan 9, 2017
There are little available toxicity data on the vast majority of chemicals in commerce. High-throughput screening (HTS) studies, such as those being carried out by the U.S. Environmental Protection Agency (EPA) ToxCast program in partnership with the...
Automated Classification and Cluster Visualization of Genotypes Derived from High Resolution Melt Curves.
PloS one
Nov 25, 2015
INTRODUCTION: High Resolution Melting (HRM) following PCR has been used to identify DNA genotypes. Fluorescent dyes bounded to double strand DNA lose their fluorescence with increasing temperature, yielding different signatures for different genotype...
Estimation of teaching-learning-based optimization primer design using regression analysis for different melting temperature calculations.
IEEE transactions on nanobioscience
Sep 12, 2014
Primers plays important role in polymerase chain reaction (PCR) experiments, thus it is necessary to select characteristic primers. Unfortunately, manual primer design manners are time-consuming and easy to get human negligence because many PCR const...
Prediction and design of thermostable proteins with a desired melting temperature.
Scientific reports
May 14, 2025
The stability of proteins at higher temperatures is crucial for their functionality, which is measured by their melting temperature (Tm). The Tm is the temperature at which 50% of the protein loses its native structure and activity. Existing methods ...
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