AIMC Topic: Amidohydrolases

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Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury.

Journal of neurophysiology Jan 8, 2020
Our previous work showed that lateral fluid percussion injury to the sensorimotor cortex (SMC) of anesthetized rats increased neuronal synaptic hyperexcitability in layer 5 (L5) neurons in ex vivo brain slices 10 days postinjury. Furthermore, endocan...
Machine Learning Animals Rats Brain Injuries, Traumatic Male Rats, Wistar Electrophysiological Phenomena Excitatory Postsynaptic Potentials Pyramidal Cells Benzodioxoles Monoacylglycerol Lipases Sensorimotor Cortex Endocannabinoids Carbamates Amidohydrolases Piperidines Succinimides Enzyme Inhibitors Benzamides Piperazines
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Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis.

Diagnostic microbiology and infectious disease Dec 30, 2018
Pyrazinamide (PZA) is a key antibiotic for the treatment of drug susceptible tuberculosis. PZA-resistance is mainly mediated by mutations in the pncA gene; however the current gold standard is a phenotypic drug susceptibility test requiring a well-ad...
Genotype Molecular Diagnostic Techniques Mycobacterium tuberculosis DNA, Bacterial Pyrazinamide Eswatini Antitubercular Agents Amidohydrolases Transition Temperature Tuberculosis, Multidrug-Resistant Microarray Analysis Humans Sensitivity and Specificity Time Factors
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Chitosan coated calcium alginate beads for covalent immobilization of acrylamidase: Process parameters and removal of acrylamide from coffee.

Food chemistry Sep 15, 2018
This study reports on removal of acrylamide from roasted coffee by acrylamidase from Cupriavidus oxalaticus ICTDB921. Chitosan coated calcium alginate beads were functionalized with citric acid as nontoxic cross linker and activated by 1-ethyl-3-(3-d...
Succinimides Kinetics Hydrogen-Ion Concentration Food Handling Microscopy, Electron, Scanning Spectroscopy, Fourier Transform Infrared Chitosan Temperature Alginates Burkholderiaceae Carbodiimides Enzymes, Immobilized Amidohydrolases Acrylamide Coffee
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Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Bioorganic & medicinal chemistry letters Dec 24, 2016
We attempted to optimize sulfonamide-based non-alkyne LpxC inhibitors by focusing on improvements in enzyme inhibitory and antibacterial activity. It was discovered that inhibitors possessing 2-aryl benzofuran as a hydrophobe exhibited good activity....
Amidohydrolases Microbial Sensitivity Tests Structure-Activity Relationship Sulfonamides Gram-Negative Bacteria Anti-Bacterial Agents Drug Resistance, Bacterial
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