AIMC Topic: Viral Proteins

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A Review of In Silico Approaches for Discovering Natural Viral Protein Inhibitors in Aquaculture Disease Control.

Journal of fish diseases
Viral diseases pose a significant threat to the sustainability of global aquaculture, causing economic losses and compromising food security. Traditional control methods often demonstrate limited effectiveness, highlighting the need for alternative a...

PhageDPO: A machine-learning based computational framework for identifying phage depolymerases.

Computers in biology and medicine
Bacteriophages (phages) are the most predominant and genetically diverse biological entities on Earth. Phages are viruses that infect bacteria and encode numerous proteins with potential biotechnological application. However, most phage-encoded prote...

Supervised learning approaches for predicting Ebola-Human Protein-Protein interactions.

Gene
The goal of this research work is to predict protein-protein interactions (PPIs) between the Ebola virus and the host who is at risk of infection. Since there are very limited databases available on the Ebola virus; we have prepared a comprehensive d...

ViroNia: LSTM based proteomics model for precise prediction of HCV.

Computers in biology and medicine
Classification of viruses carries important implications in terms of understanding their evolution and the designing of interventions. This study introduces ViroNia as a novel LSTM-based system specifically meant for high-accuracy classification of v...

High-throughput Kinetics using capillary Electrophoresis and Robotics (HiKER) platform used to study T7, T3, and Sp6 RNA polymerase misincorporation.

PloS one
T7 RNA Polymerase (RNAP) is a widely used enzyme with recent applications in the production of RNA vaccines. For over 50 years denaturing sequencing gels have been used as key analysis tools for probing the nucleotide addition mechanisms of T7 RNAP a...

Predicting viral proteins that evade the innate immune system: a machine learning-based immunoinformatics tool.

BMC bioinformatics
Viral proteins that evade the host's innate immune response play a crucial role in pathogenesis, significantly impacting viral infections and potential therapeutic strategies. Identifying these proteins through traditional methods is challenging and ...

Prediction of viral oncoproteins through the combination of generative adversarial networks and machine learning techniques.

Scientific reports
Viral oncoproteins play crucial roles in transforming normal cells into cancer cells, representing a significant factor in the etiology of various cancers. Traditionally, identifying these oncoproteins is both time-consuming and costly. With advancem...

Machine learning, network pharmacology, and molecular dynamics reveal potent cyclopeptide inhibitors against dengue virus proteins.

Molecular diversity
The dengue virus is a major global health hazard responsible for an estimated 390 million diseases yearly. This study focused on identifying cyclopeptide inhibitors for envelope structural proteins E, NS1, NS3, and NS5. Additionally, 5579 cyclopeptid...

Benchmarking machine learning robustness in Covid-19 genome sequence classification.

Scientific reports
The rapid spread of the COVID-19 pandemic has resulted in an unprecedented amount of sequence data of the SARS-CoV-2 genome-millions of sequences and counting. This amount of data, while being orders of magnitude beyond the capacity of traditional ap...