AIMC Topic: Vitamin K Epoxide Reductases

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Automated warfarin dose prediction for Asian, American, and Caucasian populations using a deep neural network.

Computers in biology and medicine Jan 13, 2023
Existing warfarin dose prediction algorithms based on pharmacogenetics and clinical parameters have not been used clinically due to the absence of external validation, lack of assessment for clinical utility, and high risk of bias. Moreover, given th...
Humans Algorithms Deep Learning Pharmacogenetics Genotype Dose-Response Relationship, Drug Anticoagulants Warfarin Vitamin K Epoxide Reductases
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Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Humans Machine Learning Algorithms Databases, Factual Female Aged Aged, 80 and over Male Middle Aged Pharmacogenetics Cohort Studies Polymorphism, Single Nucleotide Genotype Anticoagulants Warfarin Thrombosis Hemorrhage Drug Administration Schedule Multivariate Analysis International Cooperation Linkage Disequilibrium Medical Errors Vitamin K Epoxide Reductases
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