AIMC Topic: Vitamin K Epoxide Reductases

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Systematic review and meta-analysis of AI accuracy in warfarin dose prediction across ethnic groups.

European journal of clinical pharmacology Jan 19, 2026
PURPOSE: The primary purpose of this study is to systematically evaluate how accurately artificial intelligence (AI) models can predict optimal warfarin dosing by incorporating both genetic variations-particularly in VKORC1 and CYP2C9-and clinical pa...
Humans Artificial Intelligence Anticoagulants Warfarin Ethnicity Cytochrome P-450 CYP2C9 Vitamin K Epoxide Reductases
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Automated warfarin dose prediction for Asian, American, and Caucasian populations using a deep neural network.

Computers in biology and medicine Jan 13, 2023
Existing warfarin dose prediction algorithms based on pharmacogenetics and clinical parameters have not been used clinically due to the absence of external validation, lack of assessment for clinical utility, and high risk of bias. Moreover, given th...
Humans Algorithms Deep Learning Pharmacogenetics Genotype Dose-Response Relationship, Drug Anticoagulants Warfarin Vitamin K Epoxide Reductases
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Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Humans Machine Learning Algorithms Databases, Factual Female Aged Aged, 80 and over Male Middle Aged Pharmacogenetics Cohort Studies Polymorphism, Single Nucleotide Genotype Anticoagulants Warfarin Thrombosis Hemorrhage Drug Administration Schedule Multivariate Analysis International Cooperation Linkage Disequilibrium Medical Errors Vitamin K Epoxide Reductases
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[Application of an interpretable neural network framework based on the LASSO-proj algorithm for warfarin dose prediction].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi Dec 25, 2025
Warfarin, a classic oral anticoagulant, is characterized by a narrow therapeutic window and considerable interindividual variability in dosing requirements. This makes precise dose adjustment challenging in clinical practice and increases the risk of...
Humans Neural Networks, Computer Algorithms Pharmacogenetics Genotype Anticoagulants Warfarin Drug Dosage Calculations Vitamin K Epoxide Reductases
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