AIMC Topic: Vorinostat
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Prediction of Side Effects Using Comprehensive Similarity Measures.
BioMed research international
Feb 27, 2020
Identifying the potential side effects of drugs is crucial in clinical trials in the pharmaceutical industry. The existing side effect prediction methods mainly focus on the chemical and biological properties of drugs. This study proposes a method th...
Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM.
Human & experimental toxicology
Jan 13, 2017
Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to inves...
Molecular mechanisms of suberoylanilide hydroxamic acid in the inhibition of TGF-β1-mediated canine corneal fibrosis.
Veterinary ophthalmology
Nov 12, 2015
OBJECTIVE: To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-indep...
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