Association of sarcopenia with all-cause and cause-specific mortality in cancer patients: development and validation of a 3-year and 5-year survival prediction model.

Journal: BMC cancer
Published Date: May 22, 2025

Abstract

BACKGROUND: Sarcopenia is a clinicopathological condition characterized by a decrease in muscle strength and muscle mass, playing a crucial role in the prognosis of cancer. Therefore, this study aims to investigate the association between sarcopenia and both all-cause mortality and cancer-specific mortality among cancer patients. Furthermore, we plan to develop risk prediction models using machine learning algorithms to predict 3-year and 5-year survival rates in cancer patients.

Authors

  • Feng Cui
    Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, 84 Lomb Memorial Drive, Rochester, New York, 14623, USA.
  • Xiangji Dang
    Department of Pharmaceutical, Lanzhou University Second Hospital, Cui Ying Men No.80, Lanzhou, 730030, Gansu Province, People's Republic of China.
  • Daiyun Peng
    Department of Nuclear Medicine, Lanzhou University Second Hospital, Cui Ying Men No.80, Lanzhou, 730030, Gansu Province, People's Republic of China.
  • Yuanhua She
    Department of General Surgery, Lanzhou University Second Hospital, Cui Ying Men No.80Gansu Province, Lanzhou, 730030, People's Republic of China.
  • Yubin Wang
    Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
  • Ruifeng Yang
    School of Second Clinical Medical, Lanzhou University, Donggang West Road No. 199, Lanzhou, 730030, Gansu Province, People's Republic of China.
  • Zhiyao Han
    School of Second Clinical Medical, Lanzhou University, Donggang West Road No. 199, Lanzhou, 730030, Gansu Province, People's Republic of China.
  • Yan Liu
    Department of Clinical Microbiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
  • Hanteng Yang
    Department of General Surgery, Lanzhou University Second Hospital, Cui Ying Men No.80Gansu Province, Lanzhou, 730030, People's Republic of China. yanghanteng@126.com.

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