Inflammatory biomarkers as predictors for unlocking antidepressant efficacy: Assessing predictive value and risk stratification in major depressive disorder in a prospective longitudinal study.

Journal: Journal of affective disorders
Published Date: May 28, 2025

Abstract

BACKGROUND: Major depressive disorder (MDD) is characterized by significant heterogeneity in treatment response, with inflammation hypothesized to play a role in its pathophysiology. Peripheral inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP), may predict antidepressant efficacy. This study investigated the association between baseline inflammatory biomarkers, their changes, and antidepressant treatment outcomes in patients with MDD.

Authors

  • Nervana Elbakary
    Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: Nelbakary@hamad.qa.
  • Noriya Al-Khuzaei
    Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: Nalkhuzaei@hamad.qa.
  • Tarteel Hussain
    College of Pharmacy, Qatar University, Doha, Qatar.
  • Ahmed Karawia
    Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: AKarawia@hamad.qa.
  • Malek Smida
    Psychiatry Medical Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: SMalek1@hamad.qa.
  • Niveen Abu-Rahma
    Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: NAburahma@hamad.qa.
  • Fairooz Akel
    Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: FAkel@hamad.qa.
  • Soad Esmail Mahmoud
    Nursing Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: SMahmoud14@hamad.qa.
  • James Currie
    Psychiatry Medical Department, Hamad Medical Corporation, Doha, Qatar. Electronic address: JCurrie@hamad.qa.
  • Mohamed Adil Shah Khoodoruth
    Psychiatry Medical Department, Hamad Medical Corporation, Doha, Qatar; Division of Child & Adolescent Psychiatry, Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, Canada.
  • Sami Ouanes
    Psychiatry Medical Department, Hamad Medical Corporation, Doha, Qatar; MindWell, Kuwait.

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