Differentiating Treatment-Resistant Depression With and Without Parkinsonism in the Elderly From a Psychiatric Perspective by Tc-TRODAT-1 SPECT Imaging.

Journal: International journal of geriatric psychiatry
Published Date: Jun 1, 2025

Abstract

OBJECTIVES: Late-life depression often overlaps with neurodegenerative diseases leading to diagnostic and treatment challenges for neuropsychiatrists. This study aimed to differentiate elderly treatment-resistant depression (TRD) comorbid with parkinsonism from elderly TRD without Parkinsonism as well as elderly healthy controls using striatum dopamine transporter (DAT) imaging by Tc TRODAT-1 SPECT.

Authors

  • Tung-Ping Su
    Department of Psychiatry, Cheng-Hsin General Hospital, Taipei, Taiwan.
  • Chiu-Jung Huang
    Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Wei-Chung Mao
    Department of Psychiatry, Cheng-Hsin General Hospital, Taipei, Taiwan.
  • Yu-Hsien Chiu
    Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Ren-Shyan Liu
    Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
  • Li-Fen Chen

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