AIMC Topic: Dopamine Plasma Membrane Transport Proteins

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Cross-modal fusion of brain imaging and clinical data for Parkinson's disease progression prediction.

PloS one Nov 20, 2025
BACKGROUND: Machine learning shows great potential in science but struggles with complex, high-dimensional multi-omics data. PD progression is long, diagnosed mainly by clinical signs. This paper proposes a novel decision fusion method to improve the...
Brain Female Aged Humans Machine Learning Parkinson Disease Neuroimaging Diffusion Tensor Imaging Dopamine Plasma Membrane Transport Proteins Male Middle Aged Disease Progression
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CNSGT: Generative Transformer for De Novo Drug Design Targeting the Central Nervous System.

Journal of chemical information and modeling Sep 26, 2025
The design of novel central nervous system (CNS) drugs presents formidable challenges due to the restrictive nature of the blood-brain barrier, which imposes stringent physicochemical requirements. Recent advances in deep learning, particularly Trans...
Dopamine Plasma Membrane Transport Proteins Humans Molecular Docking Simulation Drug Design Central Nervous System Agents Central Nervous System Deep Learning Molecular Dynamics Simulation
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Fully automatic categorical analysis of striatal subregions in dopamine transporter SPECT using a convolutional neural network.

Annals of nuclear medicine Mar 16, 2025
OBJECTIVE: To provide fully automatic scanner-independent 5-level categorization of the [I]FP-CIT uptake in striatal subregions in dopamine transporter SPECT.
Convolutional Neural Networks Image Processing, Computer-Assisted Automation Adult Male Middle Aged Dopamine Plasma Membrane Transport Proteins Corpus Striatum Tomography, Emission-Computed, Single-Photon Tropanes Humans Female Aged
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Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit.

CPT: pharmacometrics & systems pharmacology Mar 5, 2025
Approximately 15% of patients suspected of having Parkinson's disease (PD) present dopamine active transporter (DaT) scans without evidence of dopaminergic deficits (SWEDD), most of which will never develop PD. Leveraging Movement Disorders Society U...
Humans Neural Networks, Computer Female Parkinson Disease Aged Dopamine Male Dopamine Plasma Membrane Transport Proteins Middle Aged
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Interpretation of basal nuclei in brain dopamine transporter scans using a deep convolutional neural network.

Nuclear medicine communications Feb 18, 2025
OBJECTIVE: Functional imaging using the dopamine transporter (DAT) as a biomarker has proven effective in assessing dopaminergic neuron degeneration in the striatum. In assessing the neuron degeneration, visual and semiquantitative methods are used t...
Image Interpretation, Computer-Assisted Tomography, Emission-Computed, Single-Photon Dopamine Plasma Membrane Transport Proteins Convolutional Neural Networks Image Processing, Computer-Assisted Parkinson Disease Male Middle Aged Deep Learning Humans Neural Networks, Computer Female Aged Brain Retrospective Studies
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Incorporating label uncertainty during the training of convolutional neural networks improves performance for the discrimination between certain and inconclusive cases in dopamine transporter SPECT.

European journal of nuclear medicine and molecular imaging Nov 27, 2024
PURPOSE: Deep convolutional neural networks (CNN) hold promise for assisting the interpretation of dopamine transporter (DAT)-SPECT. For improved communication of uncertainty to the user it is crucial to reliably discriminate certain from inconclusiv...
Humans Dopamine Plasma Membrane Transport Proteins Image Processing, Computer-Assisted Neural Networks, Computer Tomography, Emission-Computed, Single-Photon Retrospective Studies Uncertainty Convolutional Neural Networks
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Artificial intelligence-based analysis of behavior and brain images in cocaine-self-administered marmosets.

Journal of neuroscience methods Sep 19, 2024
BACKGROUND: The sophisticated behavioral and cognitive repertoires of non-human primates (NHPs) make them suitable subjects for studies involving cocaine self-administration (SA) schedules. However, ethical considerations, adherence to the 3Rs princi...
Dopamine Uptake Inhibitors Dopamine Plasma Membrane Transport Proteins Callithrix Cocaine Behavior, Animal Self Administration Cocaine-Related Disorders Female Artificial Intelligence Male Animals Algorithms Positron-Emission Tomography Brain
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Unrealistic Data Augmentation Improves the Robustness of Deep Learning-Based Classification of Dopamine Transporter SPECT Against Variability Between Sites and Between Cameras.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine Sep 3, 2024
We propose strongly unrealistic data augmentation to improve the robustness of convolutional neural networks (CNNs) for automatic classification of dopamine transporter SPECT against the variability between sites and between cameras. A CNN was train...
Humans Deep Learning Dopamine Plasma Membrane Transport Proteins Image Processing, Computer-Assisted Tomography, Emission-Computed, Single-Photon
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Machine learning for predicting cognitive decline within five years in Parkinson's disease: Comparing cognitive assessment scales with DAT SPECT and clinical biomarkers.

PloS one Jul 17, 2024
OBJECTIVE: Parkinson's disease (PD) is an age-related neurodegenerative condition characterized mostly by motor symptoms. Although a wide range of non-motor symptoms (NMS) are frequently experienced by PD patients. One of the important and common NMS...
Parkinson Disease Humans Middle Aged Tomography, Emission-Computed, Single-Photon Machine Learning Female Disease Progression Biomarkers Dopamine Plasma Membrane Transport Proteins Aged Cognitive Dysfunction Male
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Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance.

European journal of nuclear medicine and molecular imaging Dec 22, 2023
PURPOSE: Deep convolutional neural networks (CNN) are promising for automatic classification of dopamine transporter (DAT)-SPECT images. Reporting the certainty of CNN-based decisions is highly desired to flag cases that might be misclassified and, t...
Tropanes Humans Uncertainty Deep Learning Dopamine Plasma Membrane Transport Proteins Tomography, Emission-Computed, Single-Photon
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