Updated perspectives on visceral pleural invasion in non-small cell lung cancer: A propensity score-matched analysis of the SEER database.

Journal: Current problems in cancer
Published Date: Apr 18, 2025

Abstract

BACKGROUND: Visceral pleural invasion (VPI), including PL1 (the tumor invades beyond the elastic layer) and PL2 (the tumor extends to the surface of the visceral pleura), plays a crucial role in staging Non-Small Cell Lung Cancer (NSCLC). However, there is a growing debate concerning the prognostic significance of PL1 and PL2. This study, therefore, conducted the analysis of the prognostic differences between PL1 and PL2 to inform more precise staging and treatment strategies.

Authors

  • Jingxin Liu
  • Yibing Wang
    Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
  • Xianwei Zhou
    Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
  • Meijin Reng
    Department of Oncology, Nanjing Drum Tower Hospital, Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, No.321 Zhongshan Road, Gulou District, Nanjing City, Jiangsu Province, China.
  • Ziyue Xiang
    Department of Oncology, Nanjing Drum Tower Hospital, Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, No.321 Zhongshan Road, Gulou District, Nanjing City, Jiangsu Province, China.
  • Ruimin Chang
    Department of Thoracic Surgery, Xiangya Hospital Central South University, Changsha 410000, China.
  • Wen Hao
    Department of Radiology, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, China.
  • Xitai Sun
    Department of Metabolic and Bariatric Surgery, The Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, China.
  • Yang Yang
    Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

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