Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.

Journal: BMJ open respiratory research
Published Date: Jun 27, 2025

Abstract

INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibility of using online proton-transfer-reaction mass spectrometry (PTR-MS) to identify distinctive breath signatures in children with allergic asthma.

Authors

  • Lamkaddam Houssni
    Laboratory of Atmospheric Chemistry, Paul Scherrer Institut PSI, Villigen, Aargau, Switzerland.
  • Micic Srdjan
    Department of Respiratory Medicine, University Children's Hospital Zürich, Zurich, Switzerland.
  • Bruderer Tobias
    Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
  • Baumann Yvette
    Department of Respiratory Medicine, University Children's Hospital Zürich, Zurich, Switzerland.
  • Di Francesco Fabio
    Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
  • Koch Patricia
    Department of Respiratory Medicine, University Children's Hospital Zürich, Zurich, Switzerland.
  • Lomonaco Tommaso
    Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
  • Prévôt André
    Laboratory of Atmospheric Chemistry, Paul Scherrer Institut PSI, Villigen, Aargau, Switzerland.
  • Prince Tiwari
    Paul Scherrer Institut PSI, Villigen, Aargau, Switzerland.
  • Reale Serena
    Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
  • Ripszam Matyas
    Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
  • Weber Ronja
    Department of Respiratory Medicine, University Children's Hospital Zürich, Zurich, Switzerland.
  • Imad El Haddad
    Laboratory of Atmospheric Chemistry, Paul Scherrer Institut PSI, Villigen, Aargau, Switzerland.
  • Alexander Moeller
    Department of Respiratory Medicine, University Children's Hospital Zürich, Zurich, Switzerland Alexander.Moeller@kispi.uzh.ch.

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