Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Journal:
Journal of nanobiotechnology
Published Date:
Jul 5, 2025
Abstract
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in the pathogenesis of OA. Recent advancements in high-throughput sequencing technologies, along with the integration of machine learning into medical research, have provided novel insights into the molecular mechanisms underlying various diseases. However, the specific roles and mechanisms of immune-related factors in OA remain poorly understood. This study aims to identify potential biomarkers for the diagnosis and monitoring of OA progression and to explore targeted therapeutic strategies based on key genes associated with the disease.
