Predicting p53 Status in IDH-Mutant Gliomas Using MRI-Based Radiomic Model.

Journal: Cancer medicine
Published Date: Aug 1, 2025

Abstract

OBJECTIVES: Accurate and noninvasive detection of p53 status in isocitrate dehydrogenase mutant (IDH-mt) glioma is clinically meaningful for molecular stratification of glioma, yet it remains challenging. We aimed to investigate the diagnostic efficacy of radiomics utilizing pre-surgery contrast-enhanced T1-weighted imaging (CE-T1WI) for predicting p53 status in IDH-mt gliomas.

Authors

  • Jiamin Li
    Guangdong Medical Universiy, Xiashan District, Zhanjiang, Guangdong, China.
  • Zhihong Lan
    Department of Radiology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated With Jinan University, Zhuhai, China.
  • Xiao Zhang
    Merck & Co., Inc., Rahway, NJ, USA.
  • Xiaoyun Liang
    The School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, People's Republic of China.
  • Hanwei Chen
    Guangzhou Panyu Central Hospital, Guangzhou, China.
  • Xiangrong Yu

Keywords

External Resources

Popular Topics
Recent Journals