Optimizing timing and cost-effective use of plasma biomarkers in Alzheimer's disease.

Journal: Alzheimer's research & therapy
Published Date: Aug 20, 2025

Abstract

BACKGROUND AND OBJECTIVES: Early and cost-effective identification of amyloid positivity is crucial for Alzheimer's disease (AD) diagnosis. While amyloid PET is the gold standard, plasma biomarkers such as phosphorylated tau 217 (pTau217) provide a potential alternative. This study evaluates the diagnostic accuracy of a combined-panel approach using machine learning models and evaluated the biomarker significance.

Authors

  • Hsin-I Chang
    Department of Neurology, Cognition and Aging Center, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta-Pei Rd., Niau-Sung Dist, Kaohsiung City, 833401, Taiwan.
  • Mi-Chia Ma
    Department of Statistics, Institute of Data Science, College of Management, National Cheng Kung University, No 1-3, Daxue Rd., East Dist, Tainan, 701, Taiwan.
  • Kuo-Lun Huang
    Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5, Fu-Hsing Street, Guishan, Taoyuan, 333, Taiwan.
  • Chung-Gue Huang
    Department of Medical Laboratory, Department of Medical Biotechnology and Laboratory Science, Linkou Chang Gung Memorial Hospital, Chang Gung University, No 5. Fuxing St., Guishan District, Taoyuan, 33305, Taiwan.
  • Shu-Hua Huang
    Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta-Pei Rd., Niau-Sung Dist, Kaohsiung City, 833401, Taiwan.
  • Chi-Wei Huang
    Department of Neurology, Cognition and Aging Center, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta-Pei Rd., Niau-Sung Dist, Kaohsiung City, 833401, Taiwan.
  • Kun-Ju Lin
    Department of Nuclear Medicine, Linkou Chang Gung Memorial Hospital, Chang Gung University, No 5. Fuxing St., Guishan District, Taoyuan, 33305, Taiwan.
  • Chiung-Chih Chang
    Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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