Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.

Journal: Psychological medicine
Published Date: Aug 29, 2025

Abstract

BACKGROUND: Identifying key areas of brain dysfunction in mental illness is critical for developing precision diagnosis and treatment. This study aimed to develop region-specific brain aging trajectory prediction models using multimodal magnetic resonance imaging (MRI) to identify similarities and differences in abnormal aging between bipolar disorder (BD) and major depressive disorder (MDD) and pinpoint key brain regions of structural and functional change specific to each disorder.

Authors

  • Jun-Ding Zhu
    Department of Occupational Therapy, https://ror.org/059ryjv25College of Medical Science and Technology, Chung Shan Medical University, Taichung, Taiwan.
  • I-Jou Chi
    https://ror.org/00se2k293Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Hui-Yun Hsu
    https://ror.org/00se2k293Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Shih-Jen Tsai
    Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan. tsai610913@gmail.com.
  • Albert C Yang
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston.

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