Early detection of Alzheimer's disease using small RNAs. Results from the EPAD cohort.

Journal: The journal of prevention of Alzheimer's disease
Published Date: Jun 28, 2025

Abstract

BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, and early diagnosis is crucial to enable effective interventions. Currently, Alzheimer's disease is diagnosed through cognitive assessments, brain imaging and fluid biomarkers focused on determining amyloid (A) and, tau (T) protein levels as well as neurodegeneration (N) in the AT(N) framework. Prognostic biomarkers for predicting cognitive decline within the amyloid positive (Aβ+) individuals would further strengthen the framework.

Authors

  • Tobias Sikosek
    Hummingbird Diagnostics GmbH, Heidelberg, Germany. Electronic address: publication@hb-dx.com.
  • Marco Heuvelman
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Jagoda Mika
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Mustafa Kahraman
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Julia Jehn
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Maurice Frank
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Alberto Daniel-Moreno
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Jessika Ceiler
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Jasmin Skottke
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Marta Sanchez-Delgado
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Patrick Neubert
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Christina Rudolf
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Kaja Tikk
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Rastislav Horos
    Hummingbird Diagnostics GmbH, Heidelberg, Germany.
  • Jeffrey L Cummings
    Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas (UNLV), Las Vegas, Nevada, USA.
  • Josie Butchart
    Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
  • Craig Ritchie
    Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
  • Jean Manson
    Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.
  • Bruno R Steinkraus
    Hummingbird Diagnostics GmbH, Heidelberg, Germany. Electronic address: publication@hb-dx.com.

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