Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma.

Journal: Oncotarget
Published Date:

Abstract

RATIONALE: Timely detection of pseudoprogression (PSP) is crucial for the management of patients with high-grade glioma (HGG) but remains difficult. Textural features of O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography (FET-PET) mirror tumor uptake heterogeneity; some of them may be associated with tumor progression.

Authors

  • Sied Kebir
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.
  • Zain Khurshid
    Department of Nuclear Medicine, University of Bonn Medical Center, Germany.
  • Florian C Gaertner
    Department of Nuclear Medicine, University of Bonn Medical Center, Germany.
  • Markus Essler
    Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
  • Elke Hattingen
    Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany.
  • Rolf Fimmers
    Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn Medical Center, Germany.
  • Björn Scheffler
    Stem Cell Pathologies Group, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Germany.
  • Ulrich Herrlinger
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.
  • Ralph A Bundschuh
    Department of Nuclear Medicine, University of Bonn Medical Center, Germany.
  • Martin Glas
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.