Chest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease.

Journal: The Lancet. Digital health
PMID: 33328086

Abstract

BACKGROUND: Deep learning-based radiological image analysis could facilitate use of chest x-rays as triage tests for pulmonary tuberculosis in resource-limited settings. We sought to determine whether commercially available chest x-ray analysis software meet WHO recommendations for minimal sensitivity and specificity as pulmonary tuberculosis triage tests.

Authors

  • Faiz Ahmad Khan
    McGill International TB Centre, Research Institute of the McGill University Health Centre and McGill University, Montreal, QC, Canada; Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Medicine and Department of Epidemiology, McGill University, Montreal, Canada. Electronic address: faiz.ahmadkhan@mcgill.ca.
  • Arman Majidulla
    Interactive Research and Development Pakistan, Karachi, Pakistan.
  • Gamuchirai Tavaziva
    McGill International TB Centre, Research Institute of the McGill University Health Centre and McGill University, Montreal, QC, Canada; Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
  • Ahsana Nazish
    The Indus Hospital, Karachi, Pakistan.
  • Syed Kumail Abidi
    McGill International TB Centre, Research Institute of the McGill University Health Centre and McGill University, Montreal, QC, Canada.
  • Andrea Benedetti
    Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Medicine and Department of Epidemiology, McGill University, Montreal, Canada.
  • Dick Menzies
    McGill International TB Centre, Research Institute of the McGill University Health Centre and McGill University, Montreal, QC, Canada; Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Medicine and Department of Epidemiology, McGill University, Montreal, Canada.
  • James C Johnston
    Ghori TB Clinic, University of British Columbia, Vancouver, BC, Canada.
  • Aamir Javed Khan
    Interactive Research and Development Global, Singapore.
  • Saima Saeed
    Global Health Directorate, Indus Health Network, Karachi, Pakistan.

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