AI Medical Compendium Journal:
Computational biology and chemistry

Showing 11 to 20 of 191 articles

Incorporating time as a third dimension in transcriptomic analysis using machine learning and explainable AI.

Computational biology and chemistry
Transcriptomic data analysis entails the measurement of RNA transcript (gene expression products) abundance in a cell or a cell population at a single point in time. In other words, transcriptomics as it is currently practiced is two-dimensional (2DT...

Application of Machine Learning (ML) approach in discovery of novel drug targets against Leishmania: A computational based approach.

Computational biology and chemistry
Molecules with potent anti-leishmanial activity play a crucial role in identifying treatments for leishmaniasis and aiding in the design of novel drugs to combat the disease, ultimately protecting individuals and populations. Various methods have bee...

Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.

Computational biology and chemistry
BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflamm...

On construction of data preprocessing for real-life SoyLeaf dataset & disease identification using Deep Learning Models.

Computational biology and chemistry
The vast volumes of data are needed to train Deep Learning Models from scratch to identify illnesses in soybean leaves. However, there is still a lack of sufficient high-quality samples. To overcome this problem, we have developed the real-life SoyLe...

PocketDTA: A pocket-based multimodal deep learning model for drug-target affinity prediction.

Computational biology and chemistry
Drug-target affinity prediction is a fundamental task in the field of drug discovery. Extracting and integrating structural information from proteins effectively is crucial to enhance the accuracy and generalization of prediction, which remains a sub...

A small-scale data driven and graph neural network based toxicity prediction method of compounds.

Computational biology and chemistry
Toxicity prediction is crucial in drug discovery, helping identify safe compounds and reduce development risks. However, the lack of known toxicity data for most compounds is a major challenge. Recently, data-driven models have gained attention as a ...

A novel intelligent framework for assessing within-host transmission dynamics of Chikungunya virus using an unsupervised stochastic neural network approach.

Computational biology and chemistry
In this study, we present a novel intelligent computing framework based on unsupervised random projection neural networks for analyzing the within-host transmission dynamics of the Chikungunya virus with an adaptive immune response. In addition to th...

Brain tumor segmentation and classification using MRI: Modified segnet model and hybrid deep learning architecture with improved texture features.

Computational biology and chemistry
Brain tumors are quickly overtaking all other causes of death worldwide. The failure to perform a timely diagnosis is the main cause of increasing the death rate. Traditional methods of brain tumor diagnosis heavily rely on the expertise of radiologi...

Taylor-dingo optimized RP-net for segmentation toward Alzheimer's disease detection and classification using deep learning.

Computational biology and chemistry
Alzheimer's Disease (AD) is a significant cause of mortality in elderly people. The diagnosing and classification of AD using conventional manual operation is a challenging issue. Here, a novel scheme, namely Recurrent Prototypical Network with Taylo...

DKCN-Net: Deep kronecker convolutional neural network-based lung disease detection with federated learning.

Computational biology and chemistry
In the healthcare field, lung disease detection techniques based on deep learning (DL) are widely used. However, achieving high stability while maintaining privacy remains a challenge. To address this, this research employs Federated Learning (FL), e...