Journal of pharmacological and toxicological methods
May 9, 2025
In this study, a behavioral model of LPS-induced abdominal nociception was developed in adult zebrafish (Danio rerio), aZF. Initially, the toxicity of different LPS concentrations was assessed. The abdominal nociceptive response to the lowest LPS con...
Journal of pharmacological and toxicological methods
Jun 20, 2022
Machine learning-based approaches in the field of drug discovery have dramatically reduced the time and cost of the laboratory process of detecting potential drug-target interactions (DTIs). Standard binary classifiers require both positive and negat...
Journal of pharmacological and toxicological methods
Oct 6, 2021
Drug-induced convulsion is a severe adverse event; however, no useful biomarkers for it have been discovered. We propose a new method for predicting drug-induced convulsions in monkeys based on heart rate variability (HRV) and a machine learning tech...
Journal of pharmacological and toxicological methods
Nov 21, 2016
The arterial blood gas (ABG) test is used to assess gas exchange in the lung, and the acid-base level in the blood. However, it is still unclear whether or not ABG test indexes correlate with paraquat (PQ) poisoning. This study investigates the predi...
Journal of pharmacological and toxicological methods
Sep 28, 2014
BACKGROUND: Modeling drug interactions is important for illustrating combined drug actions and for predicting the pharmacological and/or toxicological effects that can be obtained using combined drug therapy.