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25-Hydroxyvitamin D3 1-alpha-Hydroxylase

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Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Frontiers in cellular and infection microbiology 39844838
BACKGROUND: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory ...
25-Hydroxyvitamin D3 1-alpha-Hydroxylase Adult Cytokines Female Genetic Predisposition to Disease Genotype Humans Leishmaniasis, Cutaneous Male Middle Aged Polymorphism, Single Nucleotide Receptors, Calcitriol Treatment Outcome Vitamin D Young Adult
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Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach.

Molecular diversity 34272637
CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1α,25(OH)D). Tyrosine kinase inhibitor such as imatinib is reported to interfere with the acti...
25-Hydroxyvitamin D3 1-alpha-Hydroxylase Algorithms Amino Acid Sequence Animals Binding Sites Databases, Pharmaceutical Drug Design Enzyme Inhibitors Humans Machine Learning Metabolic Networks and Pathways Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Neural Networks, Computer Phosphotransferases Protein Binding Reproducibility of Results Small Molecule Libraries Structure-Activity Relationship Support Vector Machine Vitamin D
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