AIMC Topic: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

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Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.

Frontiers in cellular and infection microbiology Jan 8, 2025
BACKGROUND: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory ...
Humans Cytokines Female Young Adult Adult Male Middle Aged Genetic Predisposition to Disease Polymorphism, Single Nucleotide Genotype Treatment Outcome Vitamin D Leishmaniasis, Cutaneous 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Receptors, Calcitriol
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Identification of kinase inhibitors that rule out the CYP27B1-mediated activation of vitamin D: an integrated machine learning and structure-based drug designing approach.

Molecular diversity Jul 16, 2021
CYP27B1, a cytochrome P450-containing hydroxylase enzyme, converts vitamin D precursor calcidiol (25-hydroxycholecalciferol) to its active form calcitriol (1α,25(OH)D). Tyrosine kinase inhibitor such as imatinib is reported to interfere with the acti...
Humans Neural Networks, Computer Machine Learning Algorithms Reproducibility of Results Animals Molecular Docking Simulation Drug Design Protein Binding Support Vector Machine Vitamin D 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Structure-Activity Relationship Metabolic Networks and Pathways Models, Molecular Molecular Dynamics Simulation Amino Acid Sequence Enzyme Inhibitors Binding Sites Small Molecule Libraries Databases, Pharmaceutical Phosphotransferases
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