AIMC Topic: Adverse Drug Reaction Reporting Systems

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Detecting adverse drug reactions in discharge summaries of electronic medical records using Readpeer.

International journal of medical informatics
BACKGROUND: Hospital discharge summaries offer a potentially rich resource to enhance pharmacovigilance efforts to evaluate drug safety in real-world clinical practice. However, it is infeasible for experts to read through all discharge summaries to ...

Smoothing dense spaces for improved relation extraction between drugs and adverse reactions.

International journal of medical informatics
BACKGROUND AND OBJECTIVE: This work aims at extracting Adverse Drug Reactions (ADRs), i.e. a harm directly caused by a drug at normal doses, from Electronic Health Records (EHRs). The lack of readily available EHRs because of confidentiality issues a...

Detecting Potential Adverse Drug Reactions Using a Deep Neural Network Model.

Journal of medical Internet research
BACKGROUND: Adverse drug reactions (ADRs) are common and are the underlying cause of over a million serious injuries and deaths each year. The most familiar method to detect ADRs is relying on spontaneous reports. Unfortunately, the low reporting rat...

Innovation in Pharmacovigilance: Use of Artificial Intelligence in Adverse Event Case Processing.

Clinical pharmacology and therapeutics
Automation of pharmaceutical safety case processing represents a significant opportunity to affect the strongest cost driver for a company's overall pharmacovigilance budget. A pilot was undertaken to test the feasibility of using artificial intellig...

Identifying health information technology related safety event reports from patient safety event report databases.

Journal of biomedical informatics
OBJECTIVE: The objective of this paper was to identify health information technology (HIT) related events from patient safety event (PSE) report free-text descriptions. A difference-based scoring approach was used to prioritize and select model featu...

Advancing the State of the Art in Clinical Natural Language Processing through Shared Tasks.

Yearbook of medical informatics
OBJECTIVES:  To review the latest scientific challenges organized in clinical Natural Language Processing (NLP) by highlighting the tasks, the most effective methodologies used, the data, and the sharing strategies.

Mining heterogeneous networks with topological features constructed from patient-contributed content for pharmacovigilance.

Artificial intelligence in medicine
Drug safety, also called pharmacovigilance, represents a serious health problem all over the world. Adverse drug reactions (ADRs) and drug-drug interactions (DDIs) are two important issues in pharmacovigilance, and how to detect drug safety signals h...

Natural Language Processing and Its Implications for the Future of Medication Safety: A Narrative Review of Recent Advances and Challenges.

Pharmacotherapy
The safety of medication use has been a priority in the United States since the late 1930s. Recently, it has gained prominence due to the increasing amount of data suggesting that a large amount of patient harm is preventable and can be mitigated wit...

Evaluation of Natural Language Processing (NLP) systems to annotate drug product labeling with MedDRA terminology.

Journal of biomedical informatics
INTRODUCTION: The FDA Adverse Event Reporting System (FAERS) is a primary data source for identifying unlabeled adverse events (AEs) in a drug or biologic drug product's postmarketing phase. Many AE reports must be reviewed by drug safety experts to ...

SSEL-ADE: A semi-supervised ensemble learning framework for extracting adverse drug events from social media.

Artificial intelligence in medicine
With the development of Web 2.0 technology, social media websites have become lucrative but under-explored data sources for extracting adverse drug events (ADEs), which is a serious health problem. Besides ADE, other semantic relation types (e.g., dr...