Contour extraction of image stacks is a basic task in medical modeling. The existing level-set methods usually suffer from some problems (e.g. serious errors around sharp features, incorrect split of topology and contour occlusions). This paper propo...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used for breast lesion differentiation. Manual segmentation in DCE-MRI is difficult and open to viewer interpretation. In this paper, an automatic segmentation method based on i...
Arrhythmia diagnosis is very significant to ensure human health. In this paper, a new model is developed for arrhythmia diagnosis. A salient feature of the algorithm is a synergistic combination of statistical and fuzzy set-based techniques. It is di...
In this paper, we introduce a new powerful scientific paradigm to understand natural and cultural processes. This new paradigm is based on two fundamental keywords: Data, as representative sample of the process we need to analyze, and Artificial Adap...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2015
Performing clustering analysis is one of the important research topics in cancer discovery using gene expression profiles, which is crucial in facilitating the successful diagnosis and treatment of cancer. While there are quite a number of research w...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2015
Proline residues are common source of kinetic complications during folding. The X-Pro peptide bond is the only peptide bond for which the stability of the cis and trans conformations is comparable. The cis-trans isomerization (CTI) of X-Pro peptide b...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2015
A major challenge in computational biology is to find simple representations of high-dimensional data that best reveal the underlying structure. In this work, we present an intuitive and easy-to-implement method based on ranked neighborhood compariso...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2015
Searching genomes to locate noncoding RNA genes with known secondary structure is an important problem in bioinformatics. In general, the secondary structure of a searched noncoding RNA is defined with a structure model constructed from the structura...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2015
Because most complex genetic diseases are caused by defects of cell signaling, illuminating a signaling cascade is essential for understanding their mechanisms. We present three novel computational algorithms to reconstruct signaling networks between...
International journal of data mining and bioinformatics
Jan 1, 2015
Protein superfamily classification deals with the problem of predicting the family membership of newly discovered amino acid sequence. Although many trivial alignment methods are already developed by previous researchers, but the present trend demand...
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