AIMC Topic: Aneuploidy
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A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy.
Nature communications
May 30, 2025
Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...
External validation of a fully automated evaluation tool: a retrospective analysis of 68,471 scored embryos.
Fertility and sterility
Oct 15, 2024
OBJECTIVE: To externally validate a fully automated embryo classification system for in vitro fertilization (IVF) treatments.
Factors affecting biochemical pregnancy loss (BPL) in preimplantation genetic testing for aneuploidy (PGT-A) cycles: machine learning-assisted identification.
Reproductive biology and endocrinology : RB&E
Aug 8, 2024
PURPOSE: To determine the factors influencing the likelihood of biochemical pregnancy loss (BPL) after transfer of a euploid embryo from preimplantation genetic testing for aneuploidy (PGT-A) cycles.
Artificial intelligence system for outcome evaluations of human in vitro fertilization-derived embryos.
Chinese medical journal
Jul 12, 2024
BACKGROUND: In vitro fertilization (IVF) has emerged as a transformative solution for infertility. However, achieving favorable live-birth outcomes remains challenging. Current clinical IVF practices in IVF involve the collection of heterogeneous emb...
Enhancing clinical utility: deep learning-based embryo scoring model for non-invasive aneuploidy prediction.
Reproductive biology and endocrinology : RB&E
May 22, 2024
BACKGROUND: The best method for selecting embryos ploidy is preimplantation genetic testing for aneuploidies (PGT-A). However, it takes more labour, money, and experience. As such, more approachable, non- invasive techniques were still needed. Analys...
The morphokinetic signature of human blastocysts with mosaicism and the clinical outcomes following transfer of embryos with low-level mosaicism.
Journal of ovarian research
Jan 9, 2024
BACKGROUND: Genetic mosaicism is commonly observed in human blastocysts. Embryos' morphokinetic feature observed from time-lapse monitoring (TLM) is helpful to predict the embryos' ploidy status in a non-invasive way. However, morphokinetic research ...
Seeking arrangements: cell contact as a cleavage-stage biomarker.
Reproductive biomedicine online
Nov 3, 2023
RESEARCH QUESTION: What can three-dimensional cell contact networks tell us about the developmental potential of cleavage-stage human embryos?
The neglected emotional drawbacks of the prioritization of embryos to transfer.
Reproductive biomedicine online
Oct 14, 2023
In recent years, increasing efforts have been made to develop advanced techniques that could predict the potential of implantation of each single embryo and prioritize the transfer of those at higher chance. The most promising include non-invasive pr...
Noninvasive genetic screening: current advances in artificial intelligence for embryo ploidy prediction.
Fertility and sterility
Jun 30, 2023
This review discusses the use of artificial intelligence (AI) algorithms in noninvasive prediction of embryo ploidy status for preimplantation genetic testing in in vitro fertilization procedures. The current gold standard, preimplantation genetic te...
How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Minerva obstetrics and gynecology
Jun 16, 2023
In-vitro fertilization (IVF) aims at overcoming the causes of infertility and lead to a healthy live birth. To maximize IVF efficiency, it is critical to identify and transfer the most competent embryo within a cohort produced by a couple during a cy...
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