AIMC Topic: Antimicrobial Peptides

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TP-LMMSG: a peptide prediction graph neural network incorporating flexible amino acid property representation.

Briefings in bioinformatics May 23, 2024
Bioactive peptide therapeutics has been a long-standing research topic. Notably, the antimicrobial peptides (AMPs) have been extensively studied for its therapeutic potential. Meanwhile, the demand for annotating other therapeutic peptides, such as a...
Neural Networks, Computer Algorithms Computational Biology Amino Acids Antimicrobial Peptides Peptides Deep Learning
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iAMPCN: a deep-learning approach for identifying antimicrobial peptides and their functional activities.

Briefings in bioinformatics Jul 20, 2023
Antimicrobial peptides (AMPs) are short peptides that play crucial roles in diverse biological processes and have various functional activities against target organisms. Due to the abuse of chemical antibiotics and microbial pathogens' increasing res...
Algorithms Antimicrobial Cationic Peptides Anti-Bacterial Agents Deep Learning Antimicrobial Peptides
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Designing antimicrobial peptides using deep learning and molecular dynamic simulations.

Briefings in bioinformatics Mar 19, 2023
With the emergence of multidrug-resistant bacteria, antimicrobial peptides (AMPs) offer promising options for replacing traditional antibiotics to treat bacterial infections, but discovering and designing AMPs using traditional methods is a time-cons...
Anti-Bacterial Agents Deep Learning Antimicrobial Peptides Gram-Negative Bacteria Gram-Positive Bacteria Antimicrobial Cationic Peptides Molecular Dynamics Simulation
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AMP-BERT: Prediction of antimicrobial peptide function based on a BERT model.

Protein science : a publication of the Protein Society Jan 1, 2023
Antimicrobial resistance is a growing health concern. Antimicrobial peptides (AMPs) disrupt harmful microorganisms by nonspecific mechanisms, making it difficult for microbes to develop resistance. Accordingly, they are promising alternatives to trad...
Antimicrobial Peptides Machine Learning
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Identification of antimicrobial peptides from the human gut microbiome using deep learning.

Nature biotechnology Jun 1, 2022
Gastrointestinal Microbiome Microbiota Humans Deep Learning Antimicrobial Peptides
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Do deep learning models make a difference in the identification of antimicrobial peptides?

Briefings in bioinformatics May 13, 2022
In the last few decades, antimicrobial peptides (AMPs) have been explored as an alternative to classical antibiotics, which in turn motivated the development of machine learning models to predict antimicrobial activities in peptides. The first genera...
Peptides Deep Learning Amino Acid Sequence Antimicrobial Peptides Machine Learning
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Accelerating the discovery of antifungal peptides using deep temporal convolutional networks.

Briefings in bioinformatics Mar 10, 2022
The application of machine intelligence in biological sciences has led to the development of several automated tools, thus enabling rapid drug discovery. Adding to this development is the ongoing COVID-19 pandemic, due to which researchers working in...
Antimicrobial Peptides Antifungal Agents Workflow Humans Databases, Factual Software Deep Learning Reproducibility of Results Algorithms ROC Curve Neural Networks, Computer Drug Discovery Artificial Intelligence
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sAMP-PFPDeep: Improving accuracy of short antimicrobial peptides prediction using three different sequence encodings and deep neural networks.

Briefings in bioinformatics Jan 17, 2022
Short antimicrobial peptides (sAMPs) belong to a significant repertoire of antimicrobial agents and are known to possess enhanced antimicrobial activity, higher stability and less toxicity to human cells, as well as less complex than other large biol...
Neural Networks, Computer Molecular Docking Simulation Antimicrobial Peptides Humans
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Machine Learning Prediction of Antimicrobial Peptides.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2022
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial peptides (AMPs) are recognized templates and some are already in c...
Machine Learning Anti-Infective Agents Antimicrobial Peptides Peptides Amino Acids
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AniAMPpred: artificial intelligence guided discovery of novel antimicrobial peptides in animal kingdom.

Briefings in bioinformatics Nov 5, 2021
With advancements in genomics, there has been substantial reduction in the cost and time of genome sequencing and has resulted in lot of data in genome databases. Antimicrobial host defense proteins provide protection against invading microbes. But c...
Databases, Genetic Workflow Web Browser Genomics Animals Algorithms Computational Biology Artificial Intelligence Genome Drug Discovery Reproducibility of Results Phylogeny Antimicrobial Peptides Machine Learning ROC Curve
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